Dydrogesterone is an eligible tool to suppress LH surge in assisted reproduction technologies (ART) cycles.

Objective: To evaluate Dydrogesterone's effectiveness in PPOS protocols for IVF/ICSI or oocyte cryopreservation, focusing on LH surge suppression and metaphase II oocyte yield.

Methods: A retrospective, comparative, single-center study of 550 IVF/ICSI and 186 oocyte cryopreservation cycles was conducted from January 2018 to December 2020. Exclusion criteria included endometriosis, previous ovarian surgery, ovarian insufficiency, and abnormal FSH/LH levels.

A Lower-Energy Pathway for the Creation of Multifunctional Silicon Suboxide Films.

The possibility of inducing structural crosslinking and densification of plasma-deposited SiO networks by controlling low-energy reaction mechanisms was investigated. For this, films were deposited for 300 s from HMDSO (2%), O (86%) and Ar (12%) mixtures at a working pressure of 15.7 Pa.

Nano-ionic Solid Electrolyte FET-Based Reservoir Computing for Efficient Temporal Data Classification and Forecasting.

Physical dynamic reservoirs are well-suited for edge systems, as they can efficiently process temporal input at a low training cost by utilizing the short-term memory of the device for in-memory computation. However, the short-term memory of two-terminal memristor-based reservoirs limits the duration of the temporal inputs, resulting in more reservoir outputs per sample for classification. Additionally, forecasting requires multiple devices (20-25) for the prediction of a single time step, and long-term forecasting requires the reintroduction of forecasted data as new input, increasing system complexity and costs.

Prevalence, awareness, treatment and control of hypertension in the Brazilian population and sociodemographic associated factors: data from National Health Survey.

Background: Hypertension is the main risk factor for cardiovascular diseases and more recent studies that estimated the prevalence of this condition considering aspects such as awareness of diagnosis, treatment, and control, revealing alarming results in the global scenario.

Objective: To estimate the prevalence and assess the factors associated with hypertension prevalence, awareness, treatment, and control.

Methods: This is a cross-sectional study based on data from the 2013 National Health Survey in Brazil.

Characterization of fillets and skins from two varieties of genetically improved farmed Nile tilapia (Oreochromis niloticus).

Genetically improved farmed tilapia (GIFT) is a strain of Nile tilapia (Oreochromis niloticus) developed for improved production and commercial parameters. Skin color, one of the characteristics distinguishing tilapia varieties, is an important phenotypic trait associated with qualitative and productive performance. This study aimed to assess fillet and skin characteristics in GIFT Nile tilapia with black and red skin phenotypes.

Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock: A Phase 2, Placebo-Controlled, Randomized Clinical Trial.

Objectives: Platelets play a critical role in the inflammatory response and coagulation. We aimed to evaluate whether the use of acetylsalicylic acid (ASA) would reduce the intensity of organ dysfunction in septic patients.

Design: Randomized, blinded, parallel-group, placebo-controlled trial.

Acute and chronic effects of physical exercise on atherosclerosis, kynurenine pathway, endothelial function and inflammation in patients with coronary artery disease: a clinical trial protocol.

Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with CAD exhibit increased levels of kynurenine (KYN) pathway (KP) metabolites, which are key products of tryptophan (TRP) catabolism and have been identified as predictive markers for cardiovascular events and atherosclerosis progression. However, the effects of exercise on KP metabolites and their influence on atherosclerosis and inflammation in these patients remain poorly understood.

Abortions and Congenital Malformations in Small Ruminants Associated with Toxic Plant Consumption in the Brazilian Semi-Arid Region.

The Northeast of Brazil is a leading region for small ruminants. However, these herds are primarily located in the semi-arid region and face significant losses due to fetal and perinatal mortality, frequently linked to the consumption of teratogenic toxic plants during pregnancy. This study investigated the clinical and epidemiological aspects related to abortions and malformations in 80 small ruminant farms in the semi-arid region of Brazil.

Matrisome analysis of NSCLC unveils clinically-important cancer-associated extracellular matrix changes.

Introduction: Non-small cell lung carcinoma (NSCLC), comprising adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), is characterized by an active desmoplastic stroma with an accumulation of extracellular matrix (ECM) proteins. ECM remodeling is a key feature of cancer progression, but the identification of specific therapeutic targets within this compartment remains challenging. Recent studies suggest a link between increased desmoplastic stroma and malignancy in NSCLC, the role of ECM proteins in disease pathogenesis remains unclear.

Exploring 4-quinolone-3-carboxamide derivatives: A versatile framework for emerging biological applications.

4-Quinolones are a pivotal class of compounds derived from the quinoline core, recognized for their broad therapeutic applications. Originating from the synthesis of chloroquine, their discovery led to nalidixic acid, the first quinolone analog to exhibit antibacterial activity, catalyzing the development of fluoroquinolones. Beyond their role as antibiotics, 4-quinolone derivatives have emerged as versatile scaffolds with demonstrated antitumor, antiviral, and antiparasitic activities, among others.

Additively manufactured ready-to-use platform using conductive recycled PLA for ketamine sensing.

The use of 3D-printed electrodes is reported fabricated from in-house conductive filament composed of a mixture of recycled poly (lactic acid) (rPLA), graphite (Gpt), and carbon black (CB) for fast detection of the abused drug ketamine. Firstly, the performance of these electrodes was evaluated in comparison to 3D-printed electrodes produced employing a commercially available conductive filament. After a simple pretreatment step (mechanical polishing), the new 3D-printed electrodes presented better performance than the electrodes produced from commercial filament in relation to peak-to-peak separation of the redox probe [Fe(CN)]/ (130 mV and 759 mV, respectively), charge transfer resistance (R = 1.

Satisfaction and Workload as Predictors of Psychological Distress in Professionals of Psychosocial Care Centers During the COVID-19 Pandemic.

Background And Aims: The COVID-19 pandemic significantly impacted the mental health of healthcare professionals, especially those working in Psychosocial Care Centers (CAPS), which are crucial services in the Brazilian mental health system. This study aimed to investigate the association between job satisfaction, workload, and psychological distress among CAPS professionals during the pandemic.

Methods: A cross-sectional study was conducted with 53 professionals from seven CAPS.

Hemodynamic effects of slower versus faster intravenous fluid bolus rates in critically ill patients: An observational study.

Purpose: We compared the immediate and sustained effects of 500 mL of crystalloid administered at slow (333 mL/h) versus fast rates (999 mL/h) on mean arterial pressure (MAP) in critically ill patients.

Materials And Methods: Hemodynamic variables were collected immediately before and every 30 min up to 60 min after the end of the infusion. The primary outcome was the adjusted difference in MAP.

The effect of telehealth on clinical outcomes in patients with hypertension and diabetes: A meta-analysis of 106,261 patients.

Introduction: Telemedicine, propelled by recent technological advancements, has transformed healthcare delivery, notably benefiting patients with chronic non-communicable diseases (NCDs) such as systemic arterial hypertension and diabetes mellitus. This meta-analysis of randomized clinical trials aimed to assess the efficacy of telehealth-based interventions on disease control rates and clinical parameters among NCD patients, including systolic and diastolic blood pressure (SBP and DBP), fasting blood glucose (FBG), and glycated hemoglobin (HbA1c) levels.

Methods: We conducted searches in PubMed, Scopus, Web of Science, and the Cochrane Database for interventional studies that compared tele-monitoring with usual care in patients with hypertension and type 2 diabetes mellitus.

Versican Proteolysis by ADAMTS: Understanding Versikine Expression in Canine Spontaneous Mammary Carcinomas.

The present study investigates VKINE, a bioactive proteolytic fragment of the proteoglycan VCAN, as a novel and significant element in the tumor extracellular matrix (ECM). Although VKINE has been recognized for its immunomodulatory potential in certain tumor types, its impact on ECM degradation and prognostic implications remains poorly understood. : This study aimed to evaluate VCAN proteolysis and its association with ADAMTS enzymes involved in extracellular matrix remodeling in spontaneous canine mammary gland cancer.

Neurometabolite and cognitive changes in hypothyroid patients in response to treatment: In-vivo H MRS study.

The disturbances in thyroid hormones lead to altered brain metabolism, function, and cognition. Neuroimaging studies have shown structural and functional changes in hypothyroidism. Present study investigates the neuro-metabolite changes in dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC) and associated decline cognitive function in hypothyroid patients before and after thyroxine treatment.

Rediscovery of Microbrachida Bierig, 1939, description of a new species from the Brazilian Amazon and its potential for biological control (Coleoptera, Staphylinidae).

The genus Microbrachida was described by Alexander Bierig based on one tiny rove beetle. Since then, it has not been studied. Recently, a set of small rove beetle specimens were collected in the heart of the Brazilian Amazon, where they occur foraging mushrooms that grow on logs of cultivated trees.

Impact of chronic toxoplasmosis in pregnancy: Association between maternal IgG antibodies against T. gondii and neurocognitive development effects.

Toxoplasmosis presents notable hazards in the context of pregnancy, impacting the health of the mother and the neurodevelopment of the fetus via immune reactions and possible vertical transmission. The maternal immune response from chronic Toxoplasma gondii (T. gondii) infection may negatively influence fetal neurodevelopment.

Impact of ABCG2 rs2231142(421C>A) Variant on the Clinical Outcomes of Patients With -mutated Non-small Cell Lung Cancer Treated With Gefitinib: A Comprehensive Meta-analysis.

Background/aim: Lung cancer accounts for the largest percentage of cancer deaths worldwide, with non-small cell lung cancer (NSCLC) being the predominant type. Gefitinib, an EGFR tyrosine kinase inhibitor (EGFR-TKI), has shown marked efficacy in NSCLC patients with an EGFR mutation. However, gefitinib resistance because of ABCG2 polymorphisms such as rs2231142(421C > A) might limit its clinical use.

Our daily helplessness: its presence and experience in the outpatient operation room of the Assisted Reproduction Clinic.

Objective: To identify the feeling of helplessness in assisted reproduction patients, along with the experience in the out patient surgical center of an assisted reproduction clinic.

Methods: A prospective study of care and psychological interventions performed in the outpatient surgical center (OSC) of the assisted reproduction clinic from January 2019 to December 2022. Patients are first seen by the nursing staff.

[Estimates of mortality from external causes in Brazil, 2010-2019: methodology for redistribution of garbage causes].

Insufficient quality of the underlying cause of death in the Brazilian Mortality Information System (SIM), acronym in Portuguese underlists violence and it is necessary to redistribute garbage causes (GC) into valid causes in public health prevention. This study estimated mortality from external causes using the GC redistribution method (GBD-Brazil) and compared it with SIM and estimated data from the GBD-IHME study from 2010 to 2019 in Brazil and its states. The GBD-Brazil GC redistribution algorithm applies previous steps of the GBD-IHME with modifications, using two criteria: proportion of target causes (valid) or reclassification of investigated causes.

Antitumoral action of carvedilol-a repositioning study of the drug incorporated into mesoporous silica MCM-41.

We have studied repositioning of carvedilol (an antihypertensive drug) incorporated into MCM-41 mesoporous silica. The repositioning proposes a reduction in the slow pace of discovery of new drugs, as well as toxicological safety and a significant reduction in high research costs, making it an attractive strategy for researchers and large pharmaceutical companies. We obtained MCM-41 bysynthesis and functionalized it by post-synthesis grafting with aminopropyltriethoxysilane (APTES) only or with folic acid (FA), which gave MCM-41-APTES and MCM-41-APTES-FA, respectively.

Caregivers' Mastery in Handling Gastrostomy at Home after Educational Intervention: Qualitative Descriptive Study.

Background: Effective hospital discharge planning is crucial, particularly in educating caregivers on handling medical devices. This education helps manage the patient's signs and symptoms, prevents post-discharge complications, and reduces early readmissions. This study aimed to understand aspects involved in the acquisition of mastery by home caregivers, in handling care of a patient who just underwent gastrostomy, after educational intervention during hospitalization and telemonitoring upon return home.