A roadmap for model-based bioprocess development.

The bioprocessing industry is undergoing a significant transformation in its approach to quality assurance, shifting from the traditional Quality by Testing (QbT) to Quality by Design (QbD). QbD, a systematic approach to quality in process development, integrates quality into process design and control, guided by regulatory frameworks. This paradigm shift enables increased operational efficiencies, reduced market time, and ensures product consistency.

Design and Development of an Edible Coating for a Ready-to-Eat Fish Product.

The application of chitosan and alginate coatings for a ready-to-eat (RTE) baked fish product was studied. An experimental design was used to investigate the effect of coating a polysaccharide concentration and glycerol addition on the safety (microbial growth) and quality (water loss and lipid oxidation) of an RTE fish product under optimal and abused storage conditions. The results showed that a chitosan coating with 1% (/) chitosan in 1% (/) acetic acid and 15% (/ chitosan) glycerol, or a 1% (/) alginate coating with no glycerol and no crosslinking, showed the best performance in controlling the tested safety and quality parameters.

A multi-purpose pilot-scale molten metal & molten salt pyrolysis reactor.

This paper describes the design features and operational details of a molten metal pyrolysis reactor. Such a reactor allows pyrolysis experimentation on biomass, aluminium-laminated plastics, mixed plastics, carbon fibre materials, etc. Experimental results on biodegradable plastic, carbon fibre composites, biomass and printed circuit boards (PCBs) are presented.

Recycling of aluminium laminated pouches and Tetra Pak cartons by molten metal pyrolysis - Pilot-scale experiments and economic analysis.

Aluminium laminated (AL) pouch packages and aluminium laminated Tetra-Pak cartons are considered unrecyclable, reducing their otherwise excellent lifecycle performance. This paper describes experimental results on pilot plant trials to recycle AL packages with a molten metal pyrolysis reactor. The experimental evidence shows that both package formats can be recycled and that clean aluminium can be recovered.

Economic assessment of a 40,000 t/y mixed plastic waste pyrolysis plant using direct heat treatment with molten metal: A case study of a plant located in Belgium.

Pyrolysis has been identified as an ideal process to recycle mixed plastic waste (MPW). This study investigates the economics of a 40,000 t/y MPW pyrolysis process, called PlastPyro, located in Belgium, to an accuracy of ±15% i.e.

Biotechnological approaches for the production of natural colorants by Talaromyces/Penicillium: A review.

There has been an increased interest in replacing synthetic colorants by colorants obtained from natural sources, especially microbial pigments. Monascus pigments have been used as natural colorings and food additives in Asia for centuries but have raised toxicity issues. Recently, Talaromyces/Penicillium species have been recognized as potential strains to produce natural pigments similar to those produced by Monascus species.

Assessment of the Dyeing Properties of the Pigments Produced by Talaromyces spp.

The high production yields of pigments by spp. and their high thermal stability have implied that industrial application interests may emerge in the food and textile industries, as they both involve subjecting the colourants to high temperatures. The present study aimed to assess the potential application of the pigments produced by spp.

Perstraction of Intracellular Pigments through Submerged Fermentation of Talaromyces spp. in a Surfactant Rich Media: A Novel Approach for Enhanced Pigment Recovery.

A high percentage of the pigments produced by spp. remains inside the cell, which could lead to a high product concentration inhibition. To overcome this issue an extractive fermentation process, perstraction, was suggested, which involves the extraction of the intracellular products out of the cell by using a two-phase system during the fermentation.

Selection of best conditions of inoculum preparation for optimum performance of the pigment production process by Talaromyces spp. using the Taguchi method.

Process optimisation techniques increasingly need to be used early on in research and development of processes for new ingredients. There are different approaches and this article illustrates the main issues at stake with a method that is an industry best practice, the Taguchi method, suggesting a procedure to assess the potential impact of its drawbacks. The Taguchi method has been widely used in various industrial sectors because it minimises the experimental requirements to define an optimum region of operation, which is particularly relevant when minimising variability is a target.

Scrap tyre recycling process with molten zinc as direct heat transfer and solids separation fluid: A new reactor concept.

Every year about 1.5 billion tyres are discarded worldwide representing a large amount of solid waste, but also a largely untapped source of raw materials. The objective of the method was to prove the concept of a novel scrap tyre recycling process which uses molten zinc as the direct heat transfer fluid and, simultaneously, uses this media to separate the solids products (i.

Novel waste printed circuit board recycling process with molten salt.

The objective of the method was to prove the concept of a novel waste PCBs recycling process which uses inert, stable molten salts as the direct heat transfer fluid and, simultaneously, uses this molten salt to separate the metal products in either liquid (solder, zinc, tin, lead, etc.) or solid (copper, gold, steel, palladium, etc.) form at the operating temperatures of 450-470 °C.