The role of oxidative stress in alterations of hematological parameters and inflammatory markers induced by early hypercholesterolemia.

Aims: The investigation of the effects of a high cholesterol diet (HD) for a short-time period on hematological parameters and the potential role of oxidative stress and inflammation markers.

Main Methods: Rabbits were fed either a control diet or a diet containing 1% cholesterol (HD) for 5-6 weeks. The plasma lipid levels, C reactive protein (CRP), total red blood cells (RBC), total white blood cells (WBC), platelet count, packed cell volume (PCV) and leukocyte formula were determined.

Antioxidant treatment reverts increased arterial Basal tone and oxidative stress in nephrectomized (5/6) hypertensive rats.

Nonischemic 5/6 nephrectomized rat (NefR) is a model of chronic kidney disease. However, little is known about vascular dysfunction and its relation with hypertension in NefR. Aims.