The Progress in Bioprinting and Its Potential Impact on Health-Related Quality of Life.

The intensive development of technologies related to human health in recent years has caused a real revolution. The transition from conventional medicine to personalized medicine, largely driven by bioprinting, is expected to have a significant positive impact on a patient's quality of life. This article aims to conduct a systematic review of bioprinting's potential impact on health-related quality of life.

Compulsory vaccination against COVID-19 in the context of the principles of the convention on human rights and biomedicine.

Introduction: At this stage of the global health crisis caused by the SARS-CoV-2 coronavirus, an increasing number of countries are considering enacting legislation requiring compulsory vaccination or implementing a mechanism to ensure mass vaccination of the population. Such policy decisions raise a number of legal and deontological issues.

Aim: The aim of the study was to analyze the legal and deontological issues related to the introduction of compulsory vaccination against COVID-19 in the context of the principles of the Convention on Human Rights and Biomedicine (Oviedo Convention).

Communication Skills Teaching Methods in Dental Education - a Review.

Communication skills of dentists have been demonstrated to be part of the good dental practice. The aim we set ourselves in this study was to review the literature related to the methods of teaching communication skills at dental faculties, and develop a handout in the Bulgarian language about leading a successful conversation with a patient.According to some authors, the most important principles for effective communication training include the use of practical exercises, clinically relevant scenarios, students' self-assessment tools, videotapes, participation of patient actors, and training in small groups.

Early neurological and cognitive impairments in subclinical cerebrovascular disease.

Background: The subclinical cerebrovascular disease (SCVD) is an important public health problem with demonstrated prognostic significance for stroke, future cognitive decline, and progression to dementia. The earliest possible detection of the silent presence of SCVD in adults at age at risk with normal functioning is very important for both clinical doctors and scientists.

Materials And Methods: Seventy-seven adult volunteers, recruited during the years 2005-2007, with mean age 58.

Mediterranean spotted fever in children in the Pazardjik region, South Bulgaria.

The objective of the present study was to analyze the clinical pattern of contemporary Mediterranean spotted fever in children and to compare it with the clinical pattern in adults. The research involved 257 children. The more common symptoms in children were severe onset, fever, rash, "tache noire," swelling of lymph nodes and enlarged liver or spleen.

Postoperative chemo-radiotherapy with temodal in patients with glioblastoma multiforme--survival rates and prognostic factors.

Unlabelled: Glioblastoma multiforme (GM) is the most malignant histological type of brain tumors. It affects the active age and independent of the applied general therapeutic methods in oncology the problem with the short survival of the patients still remains. In the recent years simultaneous application of Temodal and radiation therapy was introduced in medical practice.

Modelling of increased homocysteine in ischaemic stroke: post-hoc cross-sectional matched case-control analysis in young patients.

Background & Purpose: Hyperhomocysteinaemia has been postulated to participate in pathogenesis of ischaemic stroke (IS). However, especially in young adults, there is possibility of significantly increased IS risk due to increased normal homocysteinaemia, i.e.

Transient ischaemic attacks and minor strokes (analyses and clinically significant comparisons).

Unlabelled: The transient ischaemic attacks (TIA) and minor strokes are independent predictors of disabling strokes with a high medical and social value.

Purpose: Analysis and comparison of the data from the clinical monitoring of TIA and minor stroke patients in correlation with the different duration of the transient neurological deficit.

Patients And Methods: 234 patients were monitored clinically in the Clinic of Cerebrovascular Diseases, University Hospital "St.

Assessment of the effect of palliative radiotherapy for cancer patients with intracranial metastases using EORTC-QOL-C30 questionnaire.

Unlabelled: Assessment of quality of life (QOL) is of crucial importance when assigning palliative radiotherapy of brain metastases in cancer patients.

Aim: To investigate the influence of whole brain radiotherapy on brain symptoms in patients with cerebral metastases; to evaluate their quality of life before and after radiation therapy using the EORTC-QOL-C30 questionnaire, as well as its influence on patients' survival.

Patients And Methods: Sixty-five patients with various locations of the primary tumor and brain metastases were included in this study.

Radionuclide therapy of cancer patients with bone metastases.

Objectives: We report our experience in the use of radionuclides in the treatment of bone metastases in patients with various primary cancers: breast cancer, prostate cancer, lung cancer, etc.

Material And Methods: Eighty-seven patients (53 women, 34 men) with bone metastases were treated for pain relief with either 32-P (71 patients) or 89-Sr (16 patients). Fifty-three of the patients had breast cancer, 27--rostate cancer, 6--lung cancer and 1--kidney cancer.

A study of plasma total homocysteine levels in healthy people.

Unlabelled: Elevated plasma levels of homocysteine have been identified as an independent risk factor for atherosclerosis.

Aim: The aim of this study was to determine the reference limits of plasma total homocysteine for Bulgarian population.

Materials And Methods: We investigated 153 healthy individuals without vitamin deficiency aged from 18 to 65 years.

Specific peculiarities in the family model of the Turkish minority in Bulgaria.

Introduction: There is a significant decrease in the average number of children in Bulgarian families during the 80s and 90s. This phenomenon is noticed even in some regions with usually higher natality, like Kurdjali, Pazardjik, Blagoevgrad, etc.

Aim: The aim of this study was to characterize the reproductive behaviour of Turkish minority in Bulgaria.