Publications by authors named "Maria Satue"
Article Synopsis
- A new posterior pole protocol effectively detects differences in retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness between multiple sclerosis (MS) patients and healthy controls, indicating its potential for early disease assessment.!* -
- Analysis involved 66 healthy eyes and 100 eyes from remitting-relapsing MS patients, categorized by the duration of their symptoms and disease conversion for better understanding of thickness variations.!* -
- Significant differences in layer thickness were found, with RNFL thickness strongly correlating to disability status (measured by EDSS) and GCL thickness being more closely tied to the duration of the disease.!*
Background: To evaluate the neuroretina and retinal vasculature of fibromyalgia (FM) patients and calculate a linear discriminant function (LDF) to improve retinal parameters' contribution to FM diagnosis.
Methods: Fifty FM patients and 232 healthy controls underwent retinal evaluation using swept-source optical coherence tomography (SS-OCT) angiography (Triton plus; Topcon) and spectral domain OCT (SD-OCT) (Spectralis; Heidelberg). The macular (m) and peripapillary (p) retinal nerve fibre layer (RNFL) and ganglion cell layer (GCL) were assessed, as was the macular vascular density.
Article Synopsis
- The study aimed to evaluate how well swept-source optical coherence tomography (SS-OCT) with angiography analysis (SS-OCTA) can identify changes in the retina and blood vessels of patients with Parkinson's disease (PD) and essential tremor (ET).
- A total of 42 PD patients, 26 ET patients, and 146 healthy controls were analyzed, focusing on specific retinal layers and macular vasculature, with results indicating significant neuro-retinal thinning in both PD and ET, but more pronounced in PD patients.
- Findings suggest that while SS-OCT can assist in diagnosing both conditions, its predictive diagnostic power, measured by a linear discriminant function, is only applicable to PD, indicating a lack of distinct differentiation
Purpose: To quantify visual and retinal changes in patients with bipolar disorder (BD) over 5 years, compared with controls.
Methods: Thirty-eight patients with BD and 122 healthy subjects underwent visual acuity (VA) evaluation, contrast sensitivity vision testing (CSV) with the Pelli Robson and CSV 1000E tests, and retinal thicknesses measurement [ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL)] using Spectralis Optical Coherence Tomography (OCT). All subjects were re-evaluated after 5 years.
Background/objective: This study aims to identify objective biomarkers of fibromyalgia (FM) by applying artificial intelligence algorithms to structural data on the neuroretina obtained using swept-source optical coherence tomography (SS-OCT).
Method: The study cohort comprised 29 FM patients and 32 control subjects. The thicknesses of complete retina, 3 retinal layers [ganglion cell layer (GCL+), GCL++ (between the inner limiting membrane and the inner nuclear layer boundaries) and retinal nerve fiber layer (RNFL)] and choroid in 9 areas around the macula were obtained using SS-OCT.
Background: The aim of this paper is to implement a system to facilitate the diagnosis of multiple sclerosis (MS) in its initial stages. It does so using a convolutional neural network (CNN) to classify images captured with swept-source optical coherence tomography (SS-OCT).
Methods: SS-OCT images from 48 control subjects and 48 recently diagnosed MS patients have been used.
This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery. Patients were assigned for surgery with CAG (group A), mPRGF (group B), or AMT (group C). Pterygium recurrence, Best Corrected Visual Acuity (BCVA), graft size (measured with anterior segment optical coherence tomography (AS-OCT)), and ocular surface symptoms (visual analogue scale (VAS) and ocular surface disease index (OSDI)) were evaluated.
View Article and Find Full Text PDFBackground: To evaluate the effect of fingolimod in visual function and neuroretinal structures in patients with multiple sclerosis (MS) for a period of 1 year.
Methods: This longitudinal and observational cohort study included 78 eyes of 78 patients with MS treated with fingolimod. All subjects were evaluated every 3 months during 12 months and compared with 32 patients treated with interferon beta.
Article Synopsis
- This study investigates the use of optical coherence tomography (OCT) and artificial intelligence to help diagnose bipolar disorder (BD) by analyzing retinal structure.* -
- Researchers examined the retinas of 17 bipolar disorder patients and 42 healthy controls, finding significant thinning in most retinal layers of BD patients, particularly in the ganglion cell and internal plexiform layers.* -
- The best-performing AI classifier achieved a 95% accuracy in distinguishing BD patients from controls, suggesting that retinal changes could be a helpful indicator in diagnosing bipolar disorder, though further research is needed.*
Materials And Methods: Twenty-five eyes of 25 patients with bipolar disorder and 74 eyes of 74 healthy controls underwent retinal measurements of retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness. Measurements were obtained using the Spectralis-OCT device with the new Posterior Pole protocol which assesses the macular area by analyzing retinal thickness in a grid of 64 (8*8) cells.
Results: Significant differences ( < 0.
Article Synopsis
- The study aims to compare retinal microvascular features in people with relapsing-remitting multiple sclerosis (MS) to healthy individuals using optical coherence tomography angiography (OCT-A).
- A total of 92 MS patients’ eyes and 149 healthy control eyes were analyzed, revealing significant reductions in vessel density in different regions of the retina among MS patients.
- The findings suggest that MS leads to decreased retinal vascularization, which could serve as a potential tool for early diagnosis and tracking disease progression, regardless of previous optic nerve inflammation.
Purpose: To evaluate the physiological changes related with age of all retinal layers thickness measurements in macular and peripapillary areas in healthy eyes.
Methods: Wide protocol scan (with a field of view of 12x9 cm) from Triton SS-OCT instrument (Topcon Corporation, Japan) was performed 463 heathy eyes from 463 healthy controls. This protocol allows to measure the thickness of the following layers: Retina, Retinal nerve fiber layer (RNFL), Ganglion cell layer (GCL +), GCL++ and choroid.
Over the past few years, surface modification of implant surfaces has gained substantial attention as a promising solution to avoid the failure of biomaterials after implantation. Although researchers suggest several strategies for surface functionalization of titanium-based implants, only a few studies have compared the osteoimmunomodulatory effects of ionic nanostructures and biofunctionalization in the same biological model. Enamel matrix derivate (EMD) and strontium are both known for their positive influences on bone cell responses.
View Article and Find Full Text PDFArticle Synopsis
- The study examines neurodegeneration in type 2 diabetes patients who do not have diabetic retinopathy, focusing on the effects of chronic systemic ischaemia and the duration of the disease on retinal health.
- Using advanced imaging techniques, researchers compared the retinal layers of 60 diabetes patients to 60 healthy individuals and found significant reductions in specific retinal areas in the diabetes group.
- Findings suggest that even early stages of type 2 diabetes can lead to retinal neurodegeneration, with chronic ischaemia exacerbating damage to retinal layers, indicating a need for closer monitoring in patients without visible eye complications.
Purpose: To assess the reproducibility of retinal and choroidal measurements in the macular and peripapillary areas using swept-source optical coherence tomography in patients with Parkinson's disease.
Methods: A total of 63 eyes of 63 patients with idiopathic Parkinson's disease were evaluated using a three-dimensional protocol of swept-source optical coherence tomography. The following layers were analyzed: full retinal thickness, retinal nerve fiber layer, ganglion cell layer, and choroid.
RNA yield and integrity are decisive for RNA analysis. However, it is often technically challenging to maintain RNA integrity throughout the entire laser capture microdissection (LCM) procedure. Since LCM studies work with low amounts of material, concerns about limited RNA yields are also important.
View Article and Find Full Text PDFPurpose: To evaluate neurodegeneration in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy and to assess the possible role of systemic vascular complications in retinal changes.
Methods: Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated.
Intra-articular (IA) injection of mesenchymal stem cells (MSCs) promotes articular cartilage repair. However, cell fate and action after transplantation remain unclear. This study aimed at evaluating the biodistribution and efficacy of MSCs after IA injection.
View Article and Find Full Text PDFPurpose: To analyze the reproducibility of macular and peripapillary thickness measurements, and optic nerve morphometric data obtained with Triton Optical coherence tomography (OCT) in a healthy population.
Study Design: Observational cross sectional study.
Material And Methods: A total of 108 eyes underwent evaluation using the Triton Swept Source-OCT.
Purpose: To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS).
Methods: A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation.
Purpose: To evaluate the ability of swept source optical coherence tomography (SS-OCT) to detect retinal changes in patients with bipolar disorder (BD).
Methods: Twenty-three patients with BD and 23 controls underwent retinal evaluation using SS deep range imaging (DRI) Triton OCT. Full retinal thickness, the ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL), and choroidal thickness were evaluated with automated segmentation software.
Purpose: To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls.
Methods: Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, including visual acuity under photopic and mesopic lighting conditions and contrast sensitivity (CSV) tests CSV 1000 and Pelli-Robson.
Purpose: To study peripapillary choroidal thickness (PPCT) around the optic disc and establish zones using a new swept source optical coherence tomography (SS-OCT) device. To evaluate PPCT differences between patients with multiple sclerosis (MS) and age- and sex-matched healthy controls.
Methods: A total of 102 healthy subjects and 51 patients with MS were consecutively recruited.
Purpose: To evaluate visual and retinal changes in patients with bipolar disorder. To analyze the correlation between structural changes and visual function parameters.
Methods: Thirty patients with bipolar disorder and 80 healthy controls underwent visual function evaluation with Early Treatment Diabetic Retinopathy Study charts at 100%, 2.
Purpose: To evaluate the ability of new Swept source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with Parkinson's disease (PD).
Design: Observational case-control cross sectional study, developed from January to May 2016.
Methods: In total, 50 eyes from 50 patients diagnosed with PD and 54 eyes of 54 healthy controls underwent retinal and choroidal assessment using SS DRI Triton OCT (Topcon), using the 3D Wide protocol.