Publications by Maria Sara Goncalves

Publications by authors named "Maria Sara Goncalves"

Eur J Gastroenterol Hepatol

October 2005

- The study analyzed four genetic polymorphisms (TNF-alpha, IL-10, CD14, and MnSOD) in 176 heavy drinkers to see if they are linked to alcoholic liver disease (ALD) compared to those without liver disease (NLD).
- Results showed no significant differences in the prevalence of these polymorphisms between those with ALD and those without, suggesting that these genetic factors may not play a role in developing ALD.
- The study concluded that there was no association between the tested polymorphisms and the presence of established ALD, challenging previous beliefs about their impact on liver disease risk.

- Maria Sara Goncalves' research primarily investigates the genetic factors contributing to alcoholic liver disease (ALD), particularly focusing on polymorphisms related to tumor necrosis factor alpha, interleukin-10, CD14 endotoxin receptor, and manganese superoxide dismutase.
- In a study involving 176 heavy drinkers, she analyzed the association of these polymorphisms with the presence and severity of ALD compared to non-liver disease controls, emphasizing genetic predispositions in this context.
- The results indicated that certain genetic variants may be linked to increased risk and more severe histological outcomes in individuals suffering from ALD, highlighting the need for further research into genetic influences on liver health in heavy drinkers.