The Plasticity of CD4CD25FOXP3CD127 T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy.

Aims: To examine changes in subpopulation of CD4CD25Foxp3CD127 T lymphocytes (Treg) and their association with the efficiency of the IFN- therapy.

Materials And Methods: Pts with mRCC who had undergone nephrectomy were treated with IFN- at a dose of 6 × 10 U/day three times a week ( = 18). An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 pts before, 2 weeks, and 2 mo after IFN- therapy and 22 normal volunteers.

Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal Seminoma.

Nuclear protein of the testis (NUT) midline carcinomas are rare aggressive carcinomas characterized by chromosomal rearrangements that involve the gene encoding the NUT. This article reviews the clinicopathologic features and the differential diagnosis of these malignancies.