Publications by authors named "Maria Rosaria Squeo"

Introduction: Carotid IMT is a recognized marker for early atherosclerotic changes and a predictor of future CV events. Previous studies showed 11% increased risk of myocardial infarction with each 0.1 mm incremental increase of carotid IMT.

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Introduction: Abnormal blood pressure response to exercise (ABPR) in athletes is considered a risk for incident hypertension, conferring a higher cardiovascular risk profile. We sought to describe the clinical cardiovascular features of athletes with ABPR and, moreover, the relationship of ABPR with occurrence of exercise-induced ventricular ectopic beats (VEBs).

Methods And Results: We enrolled 1460 elite athletes (56.

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Introduction: Metabolic syndrome (MS) is a growing global public health concern that is associated with increased risk for cardiovascular events, even in athletes. The lipid accumulation product (LAP) index and cardiometabolic index (CMI) have been shown to be efficient markers of MS in the general population; its applicability in athletes has not been discussed yet. We aimed to assess the role of LAP and CMI in predicting MS in athletes.

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  • The study analyzed cardiac differences among Olympic athletes based on their foot racing discipline (sprints, middle, and long distances), focusing on morpho-functional parameters.
  • In total, 140 athletes were categorized into four groups based on their racing distances and underwent screenings including echocardiography and exercise stress tests.
  • Results indicated that sprinters and 400m runners generally had normal heart geometry, while middle and long-distance runners displayed significant eccentric cardiac remodeling, highlighting how training intensity and distance affect heart structure.
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Aims: Cardiac magnetic resonance (CMR) has a growing role in evaluating athletes' hearts. Mapping techniques provide added value for tissue characterization, but data on athletes and sports disciplines are lacking. To describe native mapping values in a cohort of Olympic athletes and evaluate the influence of sports discipline and sex.

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  • - Physical activity is generally beneficial for heart health, but recent research indicates that high-volume endurance exercise might actually worsen coronary atherosclerosis, leading to concerns in treating coronary artery disease (CAD) in athletes.
  • - CAD is a major cause of sudden cardiac death in athletes over 35, prompting studies to assess the prevalence of CAD in this group and its implications for health outcomes.
  • - While earlier beliefs suggested that coronary plaques in elite athletes were harmless, recent studies challenge this view, highlighting potential risks associated with exercise-induced coronary calcification and the need for better evaluation and management strategies.
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Background: Supraventricular extra beats (SVEB) are frequently observed in athletes but data on significance, prognostic role and correlation with cardiac remodeling are contrasting. It is uncertain whether SVEB may indicate the development of more complex arrhythmias and the need for closer monitoring is undetermined. The aim was to assess the prevalence and clinical significance of BESV in Olympic athletes of different sporting disciplines, evaluating potential correlations with cardiac remodeling and clinical features.

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Background: Previous studies demonstrated that variations of fT3, even within the euthyroid range, can influence cardiac function. Our aim was to investigate whether thyroid hormones, even within the euthyroid range, are associated with the magnitude of exercise-induced cardiac remodeling in Olympic athletes.

Methods: We evaluated 1342 Olympic athletes (mean age 25.

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Dyslipidemia is a major contributor to the development of atherosclerotic cardiovascular disease. Despite high level of physical activity, athletes are not immune from dyslipidemia, but longitudinal data on the variation of lipids are currently lacking. We sought to assess lipid profile changes over time in Olympic athletes practicing different sports disciplines (power, skills, endurance, and mixed).

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According to the ESC guidelines, sport disciplines are classified in relation to the predominant component (skill, power, mixed and endurance), including a wide range of disciplines with different isometric/isotonic exercises and exercise-induced heart remodeling. The aim of our study was to evaluate differences in morpho-functional cardiac adaptations in power athletes, comparing judokas with weightlifters. We enrolled 55 Olympic athletes (38 judokas, 17 weightlifters), aged 24.

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Introduction: Ethnic and gender differences in plasma lipid composition have been widely reported among the general population, but there are scarce data on athletes.

Aim: To assess ethnic and gender differences in lipid profile across a large cohort of Olympic athletes practicing different sport disciplines METHODS: We enrolled 1165 Olympic athletes divided into power, endurance, and mixed disciplines according to European Society of Cardiology classification. Sixty-two (5.

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Introduction: Recently, European Society of Cardiology (ESC) validated a prediction model to estimate 10-year fatal and non-fatal cardiovascular disease risk (CVDR) in individuals (aged 40-60 years) without previous cardiovascular disease or diabetes (ESC-SCORE2) and to provide indications for treatment. At present, data describing the CVDR in Paralympic athletes (PAs) are scarce and inconsistent. Therefore, we sought to assess the prevalence of risk factors in PAs to estimate their CVDR through SCORE2.

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Dyslipidemia is the most frequent cardiovascular (CV) risk factor in able-bodied athletes and is frequently undertreated, resulting in an underestimated risk of atherosclerosis-related diseases. Data on lipid profile in Paralympic athletes are lacking. Our study aimed to identify the prevalence of dyslipidemia and the influence of disability type and sporting discipline in Paralympic athletes.

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  • The study explored the presence of cardiac remodelling, specifically eccentric hypertrophy (EH), in 309 endurance athletes and sought to identify those without this adaptation, known as normal geometry (NG).
  • Among athletes studied, 67% of males and 68.5% of females exhibited EH, while a notable number (31.3% of males and 31.4% of females) showed NG characteristics.
  • Athletes with NG demonstrated lower peak power outputs and higher resting heart rates compared to those with EH; however, both groups did not show significant differences in their athletic achievements.
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Background: Cardiac magnetic resonance (CMR) provides information on morpho-functional abnormalities and myocardial tissue characterisation. Appropriate indications for CMR in athletes are uncertain.

Objective: To analyse the CMR performed at our Institute to evaluate variables associated with pathologic findings in a large cohort of athletes presenting with different clinical conditions.

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Introduction: Left ventricular (LV) trabeculations (LVTs) are common findings in athletes. Limited information exists regarding clinical significance, management, and outcome.

Objectives: The purpose of this study is to examine the prevalence and morphologic characteristics of LVTs in elite athletes, with a focus on clinical correlates and prognostic significance.

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Background: Athlete's heart is associated with physiological electrical and structural remodelling. Despite the plethora of data published on male athletes, solid data derived from female athletes, compared to male counterparts or sedentary women, are still scarce.

Objectives: We aimed to analyze the electrical, structural, and functional characteristics of athlete's heart in female and male athletes vs sedentary controls.

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  • Uricemia is linked to cardiovascular disease and is elevated in 4.4% of Olympic athletes, lower than the general population; males show higher levels than females.
  • The study categorizes athletes into four disciplines and measures various health indicators, finding correlations between hyperuricemia and factors like hypertension and body fat.
  • Despite being generally healthy, the presence of multiple cardiovascular risk factors in athletes suggests that monitoring uric acid levels is important for assessing their overall cardiovascular health.
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  • The study examined right ventricular (RV) changes in 370 elite athletes during the Tokyo and Beijing Olympics, focusing on differences based on gender and type of exercise (isometric vs. isotonic).
  • Isotonic athletes displayed greater RV remodeling with notable differences in size measurements compared to isometric athletes, while males generally had larger RV and right atrium sizes but with lower RV TDI velocities.
  • Although RV morphological changes varied by exercise type, functional differences were minimal, with female athletes showing unique RV profiles in terms of specific velocity measurements.
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Dyslipidemia is a major risk factor for atherosclerosis. Identification of dyslipidemia in athletes has raised interest in establishing preventive strategies and reducing cardiovascular (CV) events. Nowadays, targets or "scores" for athletes are undefined.

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Background: The Tokyo Olympic games were the only games postponed for a year in peacetime, which will be remembered as the COVID-19 Olympics. No data are currently available on the effect on athlete's performance.

Aim: To examine the Italian Olympic athletes who have undergone the return to play (RTP) protocol after COVID-19 and their Olympic results.

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Female physiology is regulated after puberty by the menstrual cycle, whose hormonal fluctuations create a multitude of effects on several systems, including the cardiovascular one. The use of hormone therapy (HT) is quite common in female athletes, and data on cardiovascular effects in this population are lacking. We sought to investigate the effects of HT in highly trained athletes to assess any difference associated with HT on cardiac remodeling, exercise capacity, and clinical correlates.

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Red yeast rice (RYR) is an entirely natural product that originates from the fermentation of white rice (Oryza sativa) with a yeast, mainly Monascus Purpureus, and has been part of traditional Chinese medicine and diet since ancient times. It has generated great interest in recent years in the context of cardiovascular (CV) prevention due to its ability to inhibit endogenous cholesterol production, helping to achieve and maintain optimal plasma lipid concentrations. This review aims to make an extensive 360-degree assessment and summary of the whole currently available scientific evidence about RYR, starting with its biochemical composition, passing through a historical reconstruction of all the studies that have evaluated its efficacy and safety in cholesterol-lowering action, with a focus on CV outcomes, and ultimately addressing its other relevant clinical effects.

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  • Bilirubin is thought to have protective effects on cardiovascular and metabolic health, with mild hyperbilirubinemia potentially providing benefits against diseases related to oxidative stress, particularly in individuals with Gilbert syndrome (GS).
  • A study involving 1,492 elite Italian athletes revealed that GS was present in 6% of participants, predominantly males, and athletes with GS showed specific hematological differences such as lower platelet counts and higher iron levels compared to those without GS.
  • No significant differences were noted in cardiac health or exercise capacity among GS athletes, although endurance athletes exhibited higher levels of total and indirect bilirubin.
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