Publications by authors named "Maria Rita Spreghini"
: Adrenoleukodystrophy (X-ALD) is a metabolic disorder caused by dysfunctional peroxisomal beta-oxidation of very-long-chain fatty acids (VLCFAs). A VLCFA-restricted Mediterranean diet has been proposed for patients and carriers to reduce daily VLCFA intake. : We retrospectively evaluated plasma VLCFAs in a cohort of 36 patients and 20 carriers at baseline and after 1 year of restricted diet.
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- A study was conducted to determine the prevalence of prediabetes in children and adolescents, exploring factors like age, obesity, insulin metabolism, and cardiovascular risk.* -
- Among 3110 participants, the prevalence of prediabetes was found to be 13.9% in children and 24.6% in adolescents, with higher rates linked to increased obesity class.* -
- The research suggests screening for prediabetes in younger obese children and adolescents and emphasizes the importance of monitoring blood pressure, triglycerides, and ALT levels in affected individuals.*
Childhood obesity is a worldwide health emergency. In many cases, it is directly linked to inappropriate eating habits and a sedentary lifestyle. During lockdown aimed at containing the coronavirus disease (COVID-19) spread, children have been forced to stay at home.
View Article and Find Full Text PDFAim: To investigate whether GE is affected in children/adolescents with obesity and abnormalities of the metabolic syndrome (MetS).
Methods: Cross-sectional study of oral GE (oGE), insulin sensitivity and secretion (calculated on 5 time-points oral glucose tolerance test) and metabolic abnormalities in 1012 patients with overweight/obesity (aged 6.0-17.
Background: To investigate the association of serum uric acid (SUA) with cardiometabolic abnormalities in Caucasian overweight/obese children (<10 years of age) versus adolescents (≥10 years of age) by drawing age and gender specific percentiles of uric acid.
Methods: Cross-sectional evaluation of 1364 Caucasian overweight/obese patients (age 4.1-17.
Aims: Insulin resistance (IR) may develop very early in life being associated with occurrence of cardiometabolic risk factors (CMRFs). Aim of the present study was to identify in young Caucasians normative values of IR as estimated by the homeostasis model assessment (HOMA-IR) and cutoffs diagnostic of CMRFs.
Methods: Anthropometrics and biochemical parameters were assessed in 2753 Caucasians (age 2-17.
Objective: To answer the question of whether onset of insulin resistance (IR) early in life enhances the risk of developing dementia and Alzheimer disease (AD), serum levels of 2 molecules that are likely associated with development of AD, the amyloid β-protein 42 (Aβ42) and presenilin 1 (PSEN1), were estimated in 101 preschoolers and 309 adolescents of various BMI.
Methods: Participants (215 boys; 48.8%) were normal weight (n = 176; 40%), overweight (n = 135; 30.
Background: Insulin sensitivity decreases at puberty transition, but little information has been provided on its earlier time-course. Aim of the present study was to describe the time-course of insulin sensitivity in severely obese children at the transition from preschool to school age.
Research Design And Methods: Retrospective study of a cohort of 47 severely obese [Body Mass Index (BMI) ≥99° percentile] preschoolers evaluated twice, once between 2 and 6 years of age, and once before age 8.
Background: To describe the morphology of glucose curve during the oral glucose tolerance test (OGTT) and any association with glucose tolerance, insulin action and secretion in obese youth.
Study Design: Cross-sectional.
Methods: OGTT data of 553 patients were analysed.
Guidelines for the establishment and operation of a donor human milk bank.
J Matern Fetal Neonatal Med
September 2010