Objective: To describe the construction of the scenarios and the development of the realistic simulation technique in health on safe administration of drugs for nursing professionals.
Method: Report of experience developed from October 2017 to May 2018 involving the steps of training of the facilitators, construction of the scenarios, development of the realistic simulation with nursing staff of a teaching hospital in the southern region of Brazil. The best simulation practice guidelines used from the International Nursing Association for Clinical Simulation and Learning.