Effect of delayed activated charcoal on acetaminophen concentration after simulated overdose of oxycodone and acetaminophen.

Objective: To determine the effect of activated charcoal (AC) on acetaminophen (APAP) absorption kinetics when administered at 1, 2, or 3 h after combined oral overdose with oxycodone.

Methods: IRB-approved, prospective cross-over study of nine healthy human volunteers ingesting 5 g of APAP + 0.5 mg/kg of oxycodone on each of four study days.