Targeting Tumor-Associated Sialic Acids Using Chimeric Switch Receptors Based on Siglec-9 Enhances the Antitumor Efficacy of Engineered T Cells.

Cancer exploits different mechanisms to escape T-cell immunosurveillance, including overexpression of checkpoint ligands, secretion of immunosuppressive molecules, and aberrant glycosylation. Herein, we report that IFNγ, a potent immunomodulator secreted in the tumor microenvironment, can induce α2,6 hypersialylation in cancer cell lines derived from various histologies. We focused on Siglec-9, a receptor for sialic acid moieties, and demonstrated that the Siglec-9+ T-cell population displayed reduced effector function.

Knowledge of Oral Cancer among the Fourth and Fifth Year Dental Students.

Background: The literature data show insufficient knowledge and awareness about oral cancer among dental and medical students.

Objective: To assess the knowledge of graduating dental students regarding oral cancer and to assess their awareness regarding the prevention and early detection of oral cancer. Also student's smoking status was examined aimed to investigate their attitude towards smoking as a risk factor for development of oral cancer and to assess the prevalence of smoking among dental students.