Penetrance, cancer incidence and survival in HFE haemochromatosis-A population-based cohort study.

Background And Aims: Haemochromatosis is characterized by progressive iron overload affecting the liver and can cause cirrhosis and hepatocellular carcinoma. Most haemochromatosis patients are homozygous for p.C282Y in HFE, but only a minority of individuals with this genotype will develop the disease.