Publications by authors named "Maria R Cucinelli"
Clin Chem Lab Med
October 2022
Article Synopsis
- The study focuses on the objectives and methodology for testing Cryofibrinogen (CF), a protein that behaves abnormally at different temperatures, highlighting its relevance in clinical diagnostics, especially in rheumatology.
- A retrospective analysis from 2019 to 2021 indicates that most CF test requests came from the rheumatology department, with a significant number of patients testing positive for CF, while isolated CF cases were notably high among those with systemic sclerosis.
- The findings suggest that the established testing protocols can help create standardized recommendations for CF analysis, emphasizing the need to include CF testing in assessments for conditions that may lead to cryofibrinogenemia.
Article Synopsis
- The kappa index (K-Index) measures intrathecal immunoglobulin synthesis using a specific ratio of cerebrospinal fluid (CSF) and serum markers, but there's little data on how consistent these measurements are across different labs.
- In a study involving 15 paired CSF and serum samples analyzed by eight laboratories, there was excellent agreement in CSF KFLC measurements and good agreement in serum KFLC across different testing methods.
- The concordance for positive K-Index results was substantial overall and very good among certain laboratories, indicating that patients are unlikely to receive conflicting results regarding K-Index positivity despite variations in testing techniques.
