Objective: Evaluate and compare the performance of autofluorescence, chemiluminescence, and clinical visual examination in the detection of oral potentially malignant disorders (OPMD), oral cancer (OC), and oropharyngeal cancer (OPC).
Materials And Methods: A systematic review with meta-analysis based on diagnostic test studies. A literature search was carried out in the MEDLINE and EMBASE databases through August 30, 2020.
To evaluate the possible involvement of epigenetic modulation by HPV16-p16 in oral potentially malignant disorder (OPMD). We generated DNA-methylation profiles, according to p16 expression and HPV16 genotype (positive or negative), of OPMD samples and p16-HPV16 negative samples (used as control), using reduced-representation bisulphite sequencing (RRBS-Seq- Illumina) technology. Twelve samples, four for each group, as follows: 1) p16+ HPV16+; 2) p16+ HPV16-; 3) p16- HPV16-, were analysed in triplicate for DNA-methylation profiles.
View Article and Find Full Text PDFThe increasing prevalence of human papilloma virus (HPV)-positive oral tumors can be considered an epidemic. Although the incidence of HPV cervical cancer is decreasing, the incidence of oral cavity and oropharyngeal cancers associated with HPV is increasing. The presence of certain HPV genotypes could be a predictor of future oral cancer lesions, although lesions associated with HPV could be less aggressive and exhibit a higher survival rate.
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