Publications by authors named "Maria R Blanco-Lopez"
Article Synopsis
- Megakaryocytes migrate to bone marrow sinusoids for platelet production, regulated by the CXCL12 chemokine and its CXCR4 receptor.
- Pim-1 kinase influences CXCR4 signaling, as inhibiting it reduces platelet aggregation and megakaryocyte migration in response to CXCL12.
- The reduction in CXCR4 signaling is due to decreased receptor levels on the surface of megakaryocytes and platelets, which has implications for treating conditions with high thrombotic risk related to elevated CXCL12.
