Publications by authors named "Maria Pitarque-Marti"
Article Synopsis
- EDF-1 is a protein that helps regulate the differentiation of endothelial cells, crucial for blood vessel formation (angiogenesis), and its expression varies during the cell cycle.
- Researchers cloned a segment of DNA upstream of the EDF-1 gene to study its promoter activity, finding it can drive gene expression in HeLa cells.
- Key binding sites for transcription factors Sp1/Sp3 and NFY were identified in the promoter region, and their removal completely abolished EDF-1 promoter activity, indicating their critical role in regulating EDF-1 expression.
Yondelis is a potent DNA-binding anticancer drug isolated from the tunicate Ecteinascidia turbinata currently undergoing phase III clinical trials. We and others have shown selective inhibition to the transcriptional induction of several genes. We tested the hypothesis that Yondelis specifically targets cell-cycle genes.
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