Caries inhibition with CO-laser during orthodontic treatment: a study protocol for a randomized split-mouth controlled clinical trial.

Introduction: White spot lesions associated with orthodontic treatment are a common problem. Recent studies reported increased resistance to acid demineralization of enamel after sub-ablative CO-laser irradiation in a combination with fluoride application. The aim of the study is to assess the efficacy of CO-laser in combination with a fluoride varnish in the prevention, severity, and extent of white spot lesions during orthodontic treatment with fixed appliances.