Publications by authors named "Maria Perez-Moreno"

Introduction: Hepatitis B virus (HBV) affects 296 million people globally, causing 780 000 annual deaths. It has been estimated that 12-43 million individuals are co-infected with hepatitis D virus (HDV). In Spain, the prevalence of HBsAg in adults is 0.

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Introduction: This systematic review, adhering to PRISMA guidelines, aimed to evaluate the efficacy and safety of antiemetic prophylaxis in haematological patients undergoing high-dose chemotherapy as part of their hematopoietic stem cell transplantation (HSCT) conditioning regimens.

Methods: We performed a comprehensive search in PubMed, EMBASE, ClinicalTrials.gov and the Cochrane database to identify randomised controlled trials (RCTs) and systematic reviews of antiemetic prophylaxis.

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Article Synopsis
  • A new calibration method for dual energy CT (DECT) using material decomposition maps for iodine and water has been developed, aimed at enhancing the accuracy of imaging.
  • Experiments conducted on a GE revolution CT scanner showed that the method successfully reproduces Hounsfield unit (HU) values with less than 1% error, validating its effectiveness.
  • This novel calibration offers comparable accuracy to existing methods, while providing better precision, making it particularly beneficial for applications like proton therapy where accurate tissue differentiation is crucial.
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Objective: Chemotherapy-induced nausea and vomiting continue to pose a significant challenge for patients undergoing hematopoietic stem cell transplantation. This study aims to synthesize available evidence on antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation, in order to identify the best standard of care.

Methods: A systematic review will be conducted using MEDLINE via PubMed, EMBASE, ClinicalTrials.

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The aim of this paper was to review the available evidence on the efficacy and safety of combined or sequential use of PD-1/PD-L1 immune checkpoint inhibitors (ICI) and CAR-T cell therapies in relapsed/refractory (R/R) haematological malignancies. A systematic literature review was performed until 21 November 2022. Inclusion criteria: cohort studies/clinical trials aimed at evaluating the efficacy and/or safety of the combination of CAR-T cell therapy with PD-1/PD-L1 inhibitors in R/R haematological malignancies, which had reported results.

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Objective: Chemotherapy-induced nausea and vomiting continue to pose a significant challenge for patients undergoing hematopoietic stem cell transplantation. This study aims to synthesize available evidence on antiemetic prophylaxis regimens in patients with hematologic malignancies undergoing hematopoietic stem cell transplantation, in order to identify the best standard of care.

Methods: A systematic review will be conducted using MEDLINE via PubMed, EMBASE, Clinical-Trials.

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Objectives: Vancomycin therapeutic drug monitoring is challenging, especially in the paediatric population where evidence is scarce. The main objective of this study was to analyse the achievement of therapeutic concentrations of vancomycin in paediatric patients and to evaluate the current monitoring method (trough levels), doses used, and the time required to achieve target concentrations.

Methods: Paediatric patients on treatment and monitored with vancomycin from November 2019 to December 2021 were included.

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Article Synopsis
  • - Medical students often experience depressive symptoms, and the COVID-19 pandemic likely worsened their mental health.
  • - A systematic review of studies from December 2019 to December 2020 found that about 31% of medical students reported depression during this period.
  • - The prevalence rates varied by region, with lower rates seen in Asia, especially China, but overall, the depression levels among medical students were similar to those reported in other university students.
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Background: Since the beginning of the COVID-19 pandemic, teachers have been accumulating adverse psychological symptoms due to the closure of educational centers and the need to adapt to different teaching modalities.

Methods: Medline and PubMed were searched for studies on the prevalence of depression, anxiety, stress, and burn-out in teachers, published from 1 December 2019 to 15 June 2021.

Results: In total, eight studies were included in this study.

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The KEYNOTE-024 clinical trial showed promising results for pembrolizumab in the first-line of treatment of advanced non-small-cell lung cancer (NSCLC). However, the profile of patients in real-world practice differs from those included in this clinical trial. Here, an observational single-center retrospective study was performed through a comparative analysis of clinical outcomes after pembrolizumab therapy according to the Eastern Cooperative Oncology Group Stage Performance Status (ECOG PS).

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  • This study reviewed data on depression levels in healthcare workers during the COVID-19 pandemic, aiming to determine the overall prevalence of depression.
  • The analysis included 57 studies from 17 countries, revealing a pooled depression rate of 24% for healthcare workers, with higher rates of 25% for nurses and 43% for frontline professionals.
  • The findings highlight that while nurses and doctors experienced similar depression rates to the general population, nearly half of frontline workers faced increased mental health challenges, indicating a need for international support and intervention.
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  • Healthcare workers faced an increased risk of anxiety during the COVID-19 pandemic, prompting a systematic review and meta-analysis to assess the prevalence of this issue.
  • The analysis included 71 studies published between December 2019 and September 2020, revealing an overall anxiety prevalence of 25%, with 27% in nurses, 17% in medical doctors, and a striking 43% in frontline workers.
  • The findings indicate significant anxiety levels among healthcare workers, particularly among nurses and those on the frontlines, highlighting the need for further longitudinal research to understand the long-term mental health effects of the pandemic.
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  • - The study reviews the impact of the COVID-19 pandemic on globally heightened anxiety levels, finding that 25% of the general population reported anxiety during this period, compared to the typical 7.3% pre-pandemic rate.
  • - Researchers analyzed data from 43 studies published between December 2019 and August 2020, identifying several risk factors for anxiety such as social isolation, unemployment, and low knowledge about the virus.
  • - These results indicate a significant deterioration in mental health due to the pandemic, highlighting the need for targeted strategies to address these anxiety levels in individuals and communities.
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Objective: Few data exist regarding the impact of antimicrobial stewardship programs on antifungal use. We evaluated the efficacy and safety of a comprehensive long-term antimicrobial stewardship program (ASP) focused on antifungal use.

Methods: During a 9-year period, we quarterly assessed antifungal consumption, incidence density of hospital-acquired candidemia, Candida spp.

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Objectives: Antibiotic stewardship programs (ASP) have already demonstrated clinical benefits. However, their effectiveness or safety in immunocompromised hosts needs to be proved.

Methods: An ecologic quasi-experimental study was performed from January 2009 to June 2017 in the Oncology department of a tertiary-care hospital.

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Objectives: To evaluate the impact of a massive online open course (MOOC) design on the appropriate use of antimicrobial agents, to determine specific study areas with better learning outcomes and to identify weak points.

Methods: A pre- and post-intervention study in the context of a training course on infectious diseases aimed at health professionals. We designed a questionnaire with 30 questions related to the management of infectious diseases in different clinical situations.

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Objectives: To describe a clinical pharmacist's (CP) activity in an emergency department (ED) regarding medication reconciliation and optimisation of pharmacotherapy of patients at hospital admission.

Methods: A 1-year prospective observational study was conducted to analyse the activity of a CP in the ED of a 350-bed hospital in Spain. The CP reviewed home medications and medical prescriptions of patients to perform medication reconciliation if required and intervene if medication errors were detected.

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Alzheimer's disease (AD) is the most common type of dementia. Recent studies have assessed the possibility of using statins as treatment for AD. However, their efficacy is not clear.

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Background: The global crisis of bacterial resistance urges the scientific community to implement intervention programs in healthcare facilities to promote an appropriate use of antibiotics. However, the clinical benefits or the impact on resistance of these interventions has not been definitively proved.

Methods: We designed a quasi-experimental intervention study with an interrupted time-series analysis.

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Objectives: To evaluate the clinical relevance of pharmacist intervention on patient care in emergencies, to determine the severity of detected errors. Second, to analyse the most frequent types of interventions and type of drugs involved and to evaluate the clinical pharmacist's activity.

Methods: A 6-month observational prospective study of pharmacist intervention in the Emergency Department (ED) at a 400-bed hospital in Spain was performed to record interventions carried out by the clinical pharmacists.

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Objective: To evaluate effectiveness and safety profile of pemetrexed in patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) when it´s used on real clinical practice in Andalusia (a Spanish region with 8.5 million inhabitants, 2014 census data).

Methods: An observational multicentre retrospective study was conducted.

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Objectives: Antibiotic treatment is vital in patients with severe sepsis/septic shock. The objectives were to assess the degree of concordance between antibiotic prescribed in emergencies and post requirements; to relate it to health outcomes (mortality) and to analyze the reasons for disagreement.

Material And Methods: Retrospective descriptive study of antibiotic treatment prescribed in emergencies and the subsequent treatment in patients with criteria of severe sepsis/septic shock in 2013.

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The aim of this study is to determine the profile of the use of pemetrexed in metastatic or locally advanced NSCLC in Andalusia and its variation over 2 years (2010-2011). A prescription-indication observational retrospective multicenter study was conducted. Adult patients with locally advanced/metastatic NSCLC who received pemetrexed in any hospital in the Andalusian Public Health System during the first term of 2010 or the last term of 2011 were included.

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