Publications by authors named "Maria Paya-Montes"
Front Mol Neurosci
August 2021
Article Synopsis
- Primary lateral sclerosis (PLS) is a progressive upper motor neuron disorder that may be related to amyotrophic lateral sclerosis (ALS) or represent a distinct group of neurodegenerative conditions, with new diagnostic criteria recently established.
- Four patients, aged 25-45, diagnosed with definite PLS showed progressive motor symptoms, mild cognitive issues initially, and results from various diagnostic tests indicating changes in the motor cortex and amyloid deposition.
- The findings suggest that PLS may be a collection of different neurodegenerative diseases, and next-generation sequencing (NGS) testing should be incorporated into diagnosis, particularly for patients with early signs or genetic predispositions.
