Publications by authors named "Maria Paula M Madruga"
PLoS Negl Trop Dis
January 2024
Article Synopsis
- Yaws is a disease caused by the bacteria Treponema pallidum subsp. pertenue (TPE) that mainly affects children in tropical rural areas, prompting a new eradication initiative due to its exclusive human reservoir.
- Researchers developed a new multi-locus sequence typing (MLST) scheme for identifying TPE strains and used it to analyze samples from a drug administration study in Papua New Guinea, finding a prevalence of 28.5% TPE DNA in collected samples.
- The study revealed low genetic diversity among TPE isolates with three main genotypes identified, and significant links between TPE positivity and factors like age and ulcer characteristics, along with a mutation in certain strains that led to azithromycin resistance.
