Publications by authors named "Maria Paola Scioli"
Article Synopsis
- - Environmental pollution significantly threatens human health, especially in relation to cardiovascular diseases (CVDs), as highlighted through various studies.
- - Epidemiological research shows a clear link between exposure to various pollutants (air, water, soil) and an increased risk of conditions like hypertension and stroke, while molecular studies identify mechanisms like oxidative stress and inflammation as contributing factors.
- - The review emphasizes the need to understand these connections for developing effective interventions and policies aimed at reducing pollution's negative impacts on cardiovascular health, underscoring the importance of preventive measures for public health.
Article Synopsis
- - This study examined aluminum (Al) levels in colon cancer samples to explore its potential link to cancer progression processes like epithelial to mesenchymal transition (EMT) and cell death, finding Al in tumor areas of 24% of sampled patients.
- - Histological and ultrastructural analyses confirmed Al's presence in colon cancer cells, showing an increase in EMT markers (vimentin, nuclear β-catenin) and a decrease in apoptotic cells in Al-positive samples compared to those without Al.
- - Multi-omic analyses revealed a higher tumor mutational burden in Al-positive colon cancers and mutations in genes related to EMT and apoptosis, suggesting that Al accumulation may influence key cancer progression pathways.
Article Synopsis
- * Exposure to toxic metals (like lead, arsenic, and mercury) may significantly contribute to the development and progression of colorectal cancer by affecting cell processes and causing DNA mutations.
- * There is a crucial need for more research to explore how toxic metal accumulation relates to colorectal cancer, which could inform preventive measures and reduce disease impact.
Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. The limited effectiveness of conventional therapies has prompted the search for new approaches to target this disease. Recent evidence suggests that distinct programmed cell death mechanisms, namely, apoptosis, ferroptosis, pyroptosis and necroptosis, play a critical role in the development and progression of cholangiocarcinoma.
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