Publications by authors named "Maria Paola Esposito"
Background And Aims: A comparison of the amino acid (AA) plasma profile and markers of intestinal absorption-inflammation between healthy subjects aged 65-70 years and age-matched patients affected by stage 3b-4 chronic kidney disease (CKD3b-4) was performed.
Methods: Eleven healthy volunteers were compared with 12 CKD3b-4 patients at their first outpatient control (T0) and after 12-months (T12). Adherence to a low protein diet (LPD, 0.
Intestinal barrier dysfunction is a risk factor for the progression of Chronic Kidney Disease (CKD). In this proof-of-concept study, we tested the effects of a mixture of Essential Amino Acids (EAAs) and mitochondrial substrates on intestinal inflammation and permeability of CKD patients. Eight patients with stage 3b-4 CKD and 11 healthy controls after overnight fasting underwent fecal measures of calprotectin and zonulin levels (indicators of gut inflammation and permeability, respectively) and determinations of plasma amino acids.
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- The study focuses on how residual renal function (RRF) and phosphate excretion (phosphaturia) influence health outcomes in patients on infrequent hemodialysis, which traditionally has received little attention.
- The authors hypothesize that increased phosphaturia can positively affect cardiovascular events and mortality in these patients, suggesting its importance in overall health management.
- Results show that patients on infrequent hemodialysis have a significant urinary phosphate output, leading to a neutral or negative phosphate balance, indicating that maintaining RRF can enhance survival and lower cardiovascular risks compared to those on more frequent dialysis.