Publications by authors named "Maria P Di Viesti"
Article Synopsis
- Remdesivir is an antiviral drug that can impede the replication of SARS-CoV-2, but studies on its impact on viral load (VL) in patients have been limited and inconsistent.
- This study analyzed the VL in two groups of COVID-19 patients—one treated with remdesivir (27 patients) and another receiving standard care (18 patients)—comparing their nasopharyngeal swab results at the start and 7-14 days after treatment.
- The results indicated that patients receiving remdesivir experienced a significantly greater reduction in VL compared to those who did not, suggesting that remdesivir may effectively lower viral loads in hospitalized COVID-19 patients.
miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Here, we show that high miR-155-5p levels are associated with unfavorable prognostic factors in two independent breast cancer cohorts (CSS cohort, = 283; and TCGA-BRCA dataset, = 1,095). Consistently, miR-155-5p results as differentially expressed in the breast cancer subgroups identified by the surrogate molecular classification in the CSS cohort and the PAM50 classifier in TCGA-BRCA dataset, with the TNBC and -amplified tumors carrying the highest levels.
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