Publications by authors named "Maria P Aguinaga"
Article Synopsis
- - Two experiments examined whether male transgenic sickle cell mice exhibit reproductive issues similar to those in men with sickle cell disease, particularly looking for signs of hypogonadism and how hydroxyurea (HU) treatment affects this condition.
- - Blood samples and sperm quality metrics were analyzed from sickle cell mice and control mice, revealing that sickle cell mice had significantly lower testosterone levels, testis weight, and sperm quality measures compared to controls, indicating they were experiencing hypogonadism.
- - In the second experiment, administering HU resulted in a significant decrease in testis weight and size over 28 and 56 days, highlighting that HU exacerbates reproductive issues in transgenic sickle cell mice.