Publications by authors named "Maria Niembro-Ortega"
Histoplasmosis is an endemic and invasive mycosis caused by . We conducted a retrospective study comparing immunosuppressed patients without human immunodeficiency virus (HIV) with a historical cohort of people with HIV and histoplasmosis. We included 199 patients with proven or probable histoplasmosis, of which 25.
View Article and Find Full Text PDFDiagnostic accuracy of antigen detection in urine and molecular assays testing in different clinical samples for the diagnosis of progressive disseminated histoplasmosis in patients living with HIV/AIDS: A prospective multicenter study in Mexico.
PLoS Negl Trop Dis
March 2021
Article Synopsis
- A multicenter study in Mexico aimed to evaluate the effectiveness of various tests for diagnosing progressive disseminated histoplasmosis (PDH) in individuals living with HIV.
- The study involved 415 participants and compared the diagnostic accuracy of urine antigen tests and nested PCR methods, confirming PDH through blood, tissue cultures, or histopathology.
- Results showed that the cHGEI IMMY test had the highest sensitivity (91.3%) among the urine tests, while nested PCR tests demonstrated varying sensitivity levels, indicating different diagnostic strengths for identifying this serious infection.
Objectives: The aim of this study was to investigate the feasibility of saliva sampling as a non-invasive and safer tool to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to compare its reproducibility and sensitivity with nasopharyngeal swab samples (NPS). The use of sample pools was also investigated.
Methods: A total of 2107 paired samples were collected from asymptomatic healthcare and office workers in Mexico City.
Latent Tuberculosis in Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Strategies to Prevent Disease Activation in an Endemic Population.
Biol Blood Marrow Transplant
July 2020
Latent tuberculosis infection (LTBI) affects one-fourth of the world´s population. Hematopoietic stem cell transplantation (HSCT) recipients are at an elevated risk of developing active tuberculosis infection (ATBI). In this retrospective study of donors and HSCT recipients who underwent transplantation between February 2000 and June 2018, our aim was to determine the prevalence of LTBI and ATBI and to describe diagnostic and therapeutic strategies in an HSCT population in an endemic region.
View Article and Find Full Text PDFDiagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: A multicenter study.
PLoS Negl Trop Dis
November 2018
Article Synopsis
- The study evaluates the diagnostic accuracy of the ALPHA Histoplasma urine antigen (HUAg) test for detecting progressive disseminated histoplasmosis (PDH) in HIV patients, particularly in Mexico.
- In a sample of 288 patients suspected of having PDH, the ALPHA-HUAg showed a sensitivity of 67.1% and a high specificity of 97.5%, indicating it is fairly good at confirming PDH but may miss some cases.
- Despite its high specificity, the low sensitivity means that ALPHA-HUAg can't be solely relied on for diagnosis, and a culture-based approach is recommended to account for potential co-infections.
Factors Associated to Prevalence and Incidence of Carbapenem-Resistant Enterobacteriaceae Fecal Carriage: A Cohort Study in a Mexican Tertiary Care Hospital.
PLoS One
June 2016
Background: Carbapenem-resistant Enterobacteriaceae (CRE) infections have emerged as a serious threat to health worldwide. They are associated with increased morbidity and mortality and are capable of silently colonizing the gastrointestinal tract. Because of this, there is great interest to characterize the epidemiology of CRE carriage and acquisition in healthcare facilities.
View Article and Find Full Text PDFOutbreak caused by Enterobacteriaceae harboring NDM-1 metallo-β-lactamase carried in an IncFII plasmid in a tertiary care hospital in Mexico City.
Antimicrob Agents Chemother
November 2015
Carbapenem-resistant Enterobacteriaceae carrying New Delhi metallo-β-lactamase 1 (NDM-1) have rarely been reported in Latin America. We report of an outbreak caused by a blaNDM-1-harboring plasmid spread through different bacterial species, including Escherichia coli (ST617) and Enterobacter cloacae (ST182) isolates from the same patient and three Klebsiella pneumoniae isolates (ST22) derived from three epidemiologically related patients. IncFII plasmids were found in all strains.
View Article and Find Full Text PDF