Publications by authors named "Maria Nicoline Baandrup Kristiansen"
Article Synopsis
- - The study evaluated how well liver biopsy analyses reflect overall liver changes during drug treatments for nonalcoholic steatohepatitis (NASH) in specially bred mice fed a high-fat diet.
- - Male Lep/Lep mice were treated with various compounds, showing that while some drugs reduced liver weight and lipid levels, one drug (elafibranor) unexpectedly increased liver size.
- - The results indicated that different compounds affected liver health metrics like inflammation and fibrosis variably, and notable histological improvements were observed, particularly with treatments like INT-767 and liraglutide.
Aim: To characterize development of diet-induced nonalcoholic steatohepatitis (NASH) by performing liver biopsy in wild-type and genetically obese mice.
Methods: Male wild-type C57BL/6J (C57) mice (DIO-NASH) and male Lep(ob) /Lep(ob) (ob/ob) mice (ob/ob-NASH) were maintained on a diet high in trans-fat (40%), fructose (22%) and cholesterol (2%) for 26 and 12 wk, respectively. A normal chow diet served as control in C57 mice (lean chow) and ob/ob mice (ob/ob chow).
Unlabelled: Having previously shown that levels of the citrullinated vimentin peptide VICM are raised in liver fibrosis in rats, we aimed to investigate whether inhibition of citrullination as measured by VICM levels could affect fibrogenesis.
Methods: Fibrogenesis was evaluated by quantitative histology and circulating levels of collagen type III in a carbon tetrachloride (CCl4) rat model of liver fibrosis for 6 weeks (n=40+10 untreated controls). The first treatment group (n=20) was treated exclusively with CCl4 for the duration of the study.