Hidden consequences: Uncovering belimumab's role in the development of pneumonia in a lupus patient.

Introduction: is an opportunistic fungal organism that can cause fatal pneumonia in immunocompromised individuals. It is a disease associated with CD4+ T cell depletion or high-dose steroids. However, there is increasing evidence that B cell dysfunction may also play a role in this illness.

Evaluation of Mitoquinone for Protecting Against Amikacin-Induced Ototoxicity in Guinea Pigs.

Hypothesis: Mitoquinone (MitoQ) attenuates amikacin ototoxicity in guinea pigs.

Background: MitoQ, a mitochondria-targeted derivative of the antioxidant ubiquinone, has improved bioavailability and demonstrated safety in humans. Thus, MitoQ is a promising therapeutic approach for protecting against amikacin-induced ototoxicity.

Ciprofloxacin Decreases Collagen in Mouse Tympanic Membrane Fibroblasts.

Objectives: To determine how collagen production by tympanic membrane fibroblasts is affected by ciprofloxacin at levels found in eardrops.

Study Design: Prospective, controlled, and blinded cell culture study.

Setting: Academic tertiary medical center.

Assessment of mitochondrial membrane potential in HEI-OC1 and LLC-PK1 cells treated with gentamicin and mitoquinone.

Objective: To determine the effects of concurrent treatment with gentamicin and the mitochondria-targeted antioxidant mitoquinone (MitoQ; which may prevent gentamicin ototoxicity) on change in the mitochondrial membrane potential (Δψ(m)), a precursor of apoptosis.

Study Design: Prospective and controlled.

Setting: Academic research laboratory.

Rheos: an implantable carotid sinus stimulation device for the nonpharmacologic treatment of resistant hypertension.

Hypertension is a highly prevalent disorder in the United States. Of particular concern is resistant hypertension, which by definition is hypertension that cannot be adequately treated by conventional 3-drug regimens. The Rheos Baroreflex Hypertension Therapy System is a new implantable device that can treat patients with hypertension resistant to multidrug therapy, by activating the carotid baroreflex through electrical stimulation of the carotid sinus wall.

The "push-to-low" approach for optimization of high-density perfusion cultures of animal cells.

High product titer is considered a strategic advantage of fed-batch over perfusion cultivation mode. The titer difference has been experimentally demonstrated and reported in the literature. However, the related theoretical aspects and strategies for optimization of perfusion processes with respect to their fed-batch counterparts have not been thoroughly explored.