Determination of the Minimal Clinically Important Difference (MCID) for Ocular Subjective Responses.

Purpose: To determine the minimal clinically important difference (MCID) for contact lens (CL)-related subjective responses and explore whether MCID values differ between subjective responses and study designs.

Methods: This was a retrospective analysis of data from seven one-week bilateral crossover studies and 14 one-day contralateral CL studies. For comfort, dryness, vision, or ease of insertion, participants rated on a 0-100 visual analogue scale (VAS) and indicated lens preference on a five-point Likert scale featuring strong, slight, and no preferences.

End-of-day assessment of asymptomatic versus highly symptomatic soft contact lens wearers.

Purpose: To investigate differences in key clinical parameters between asymptomatic and highly symptomatic soft contact lens (CL) wearers after 14 h of wear.

Methods: In this pilot investigation, Phase 1 identified asymptomatic (CLDEQ-8 score ≤ 7) and highly symptomatic (CLDEQ-8 score ≥ 20) subjects after fitting with nelfilcon A CLs. Phase 2 investigated the following over a single nelfilcon A CL-wearing day (14 ± 2 h): blinking characteristics, tear meniscus height (TMH), non-invasive tear break-up time (NIBUT), tear film osmolarity and eyelid margin staining.

The short-term effect of contact lens wear on blink characteristics.

Purpose: The aim of this pilot study was to investigate the initial effect of contact lens wear on spontaneous blink characteristics.

Methods: This was a randomised, crossover pilot study. Spontaneous blinking was recorded using a high-speed infrared camera in ten subjects with three different soft contact lenses (spherical hydrogel, spherical silicone hydrogel and toric hydrogel), one rigid contact lens and without contact lenses.

Using face masks with spectacles versus contact lenses.

Purpose: To test the hypothesis that various subjective ocular and task-related parameters associated with wearing a face mask would be better in neophyte contact lens (CL) wear compared to habitual spectacle (Sp) wear.

Methods: Thirty participants were randomised to continue in Sp (n = 15) or wear somofilcon A daily disposable CL (n = 15) ('group'). A surgical face mask (Type II R) was worn for at least one hour per day on four or more days per week.

CLEAR - Effect of contact lens materials and designs on the anatomy and physiology of the eye.

This paper outlines changes to the ocular surface caused by contact lenses and their degree of clinical significance. Substantial research and development to improve oxygen permeability of rigid and soft contact lenses has meant that in many countries the issues caused by hypoxia to the ocular surface have largely been negated. The ability of contact lenses to change the axial growth characteristics of the globe is being utilised to help reduce the myopia pandemic and several studies and meta-analyses have shown that wearing orthokeratology lenses or soft multifocal contact lenses can reduce axial length growth (and hence myopia).

The association of comfort and vision in soft toric contact lens wear.

Purpose: This work set out to investigate if there was an association between subjective comfort and both subjective and measured vision during the use of contemporary daily disposable soft toric contact lenses.

Methods: Thirty-eight habitual soft contact lens wearers wore each of three daily disposable toric lenses for one week in a prospective, crossover, randomised, single-masked study. The following clinical measures were recorded at dispensing and follow-up visits: biomicroscopy scores, lens fitting (including rotation and rotational stability), high and low contrast visual acuity, subjective vision quality and subjective ocular surface comfort.

Characterisation of blink dynamics using a high-speed infrared imaging system.

Purpose: Development and validation of a non-invasive imaging system to capture spontaneous blinking and characterise blink dynamics using a custom image analysis algorithm.

Methods: A pilot study investigated the influence of illumination type on blink dynamics. Spontaneous blinking was recorded in eight subjects using a high-speed camera under two illumination conditions: white light and infrared.

Monitoring ocular discomfort using a wrist-mounted electronic logger.

Purpose: To investigate ocular discomfort during contact lens wear using a wrist-mounted electronic 'lens awareness logger' (LAL).

Methods: Thirty symptomatic contact lens wearers wore study contact lenses for three days. On the first two days, two lens types which are known to differ in end-of-day comfort (lens A: senofilcon A and lens B: balafilcon A), were worn as a matching pair (randomised order).

The impact of contact lens wear on ocular surface mucins using a novel clinical fluorescence imaging system.

Purpose: Fluorescein-labelled wheat germ agglutinin (F-WGA) acts as a marker for ocular surface mucins. This clinical study sought to investigate whether the degree of F-WGA fluorescence observed at the ocular surface differed between symptomatic contact lens wearers, asymptomatic contact lens wearers and non-contact lens wearers, using a novel imaging system.

Methods: Twenty-five participants (10 symptomatic contact lens wearers, 10 asymptomatic contact lens wearers and 5 non-contact lens wearers) attended a single study visit.

Characterization of Upper Eyelid Tarsus and Lid Wiper Dimensions.

Objectives: To measure various dimensions of the upper tarsal plate and the area of upper lid wiper staining. The repeatability of the method of measurement was investigated.

Methods: Thirty-five healthy non-contact lens wearers were enrolled.

Effect of Three Interventions on Contact Lens Comfort in Symptomatic Wearers: A Randomized Clinical Trial.

Purpose: To investigate whether carrying out various interventions part way through the day influences comfort in symptomatic daily disposable (DD) contact lens wearers.

Methods: A subject-masked, randomized, controlled clinical trial was conducted in thirty symptomatic soft lens wearers who wore their habitual DD contact lenses bilaterally for 12 h on two separate days. Five hours after lens application, one of the following three interventions or a control was performed on each eye: replacing the existing lens with a new lens; removing and reapplying the same lens; performing a 'scleral swish'; and no action (control).

Lid Margin Sensitivity and Staining in Contact Lens Wear Versus No Lens Wear.

Purpose: To map the sensitivity and staining of the marginal conjunctiva in soft contact lens (SCL) wearers and nonwearers and to investigate diurnal changes.

Methods: Thirty-five nonwearers and 35 SCL wearers were recruited. Mechanical sensitivity was measured at 8 locations on the ocular surface and adnexa (cornea, marginal, bulbar, and tarsal conjunctivae) using the Cochet-Bonnet aesthesiometer.

Mechanical sensitivity of the human conjunctiva.

Purpose: The aim of this study was to map the sensitivity of the marginal and other conjunctival regions and to investigate changes in the sensitivity of these regions when determined in the morning and evening.

Methods: Thirty-five healthy, noncontact lens wearers (20 female, 15 male; age 27.7 ± 7.