Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/near Gene with Obesity-Related Biomarkers in a Spanish Pediatric Cohort.

Obesity is a multifactorial disease whose onset and development are shaped by the individual genetic background. The melanocortin 4 receptor gene () is involved in the regulation of food intake and energy expenditure. Some of the single nucleotide polymorphisms (SNPs) of this gene are related to obesity and metabolic risk factors.

Short Sleep Duration Is Related to Emerging Cardiovascular Risk Factors in Obese Children.

Objective: The aim of the present study was to evaluate the influence of sleep duration on cardiovascular risk factors in obese children.

Methods: Cross-sectional analysis of 90 obese children ages 7 to 16 years. Anthropometric and clinical evaluation with specification of dietary and lifestyle habits was carried out during an office visit.

Plasma resistin levels are associated with homocysteine, endothelial activation, and nitrosative stress in obese youths.

Objective: To evaluate whether serum resistin levels are related to cardiovascular risk in obese children.

Design And Methods: Cross-sectional study of 110 children (40 normal weight and 70 severely obese). Clinical and biochemical parameters, including lipid profile, fasting glucose and insulin, and homocysteine, were determined.