Publications by authors named "Maria Navalon-Lopez"
Nanomedicine is a field at the intersection of nanotechnology and medicine, promising due to its potential to revolutionize healthcare. Despite its long trajectory, there is still a long road ahead for its full development, and smart design of nanomedicines is still a challenge. Among other problems, this is due to the scarcity of tools available for the precise visualization and comprehension of nano-bio interactions, impeding progress towards the clinical phase.
View Article and Find Full Text PDFNitric oxide (NO) is a small vasodilator playing a key role in the pathogenesis of portal hypertension. Here, we assessed the potential therapeutic effect of a NO donor targeted to the liver by poly(beta-amino ester) nanoparticles (pBAE NPs) in experimental cirrhosis. Retinol-functionalized NO donor pBAE NPs (Ret pBAE NPs) were synthetized with the aim of actively targeting the liver.
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- Oligopeptide end-modified poly(β-amino ester)s (OM-pBAEs) are promising for gene therapy due to their high effectiveness and low toxicity, achieving precise targeting and biodegradability.
- The study investigates how different combinations of oligopeptides impact the properties and behaviors of these gene carriers, revealing unique strengths based on the amino acids used.
- Findings show that arginine and lysine enhance adhesion properties, while histidine increases stability, highlighting how these modifications can enhance the ability of OM-pBAEs to deliver genetic material successfully.
Vaccination has been one of the major successes of modern society and is indispensable in controlling and preventing disease. Traditional vaccines were composed of entire or fractions of the infectious agent. However, challenges remain, and new vaccine technologies are mandatory.
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