Polymorphs and solvates of nicardipine hydrochloride. Selective stabilization of different diastereomeric racemates.

Molecular understanding of the drug nicardipine hydrochloride (NHc) is provided within this study. For this reason, the polymorphism and crystal structures, including stereochemistry, of the known and the new discovered polymorphs of NHc are discussed. Three new crystalline forms of the nicardipine hydrochloride drug have been isolated: (i) a bishydrated phase, (ii) a chloroform solvate and (iii) a toluene hemisolvate.