Publications by authors named "Maria Mukhanova"
Article Synopsis
- The evolution of animals and their gut bacteria is complex, especially in social insects like cephalotine ants, where stable relationships between hosts and their symbionts may arise from transmission among relatives.
- Researchers conducted phylogenetic studies on gut bacteria from various ant species, identifying 18 distinct symbiont lineages and finding evidence of domestication events in some.
- Analysis showed that some bacteria co-diversify with their hosts while others can switch hosts, raising questions about the evolutionary dynamics between ants and their gut microbiomes.
Calorie restriction increases lifespan. Among the tissue-specific protective effects of calorie restriction, the impact on the gastrointestinal tract remains unclear. We report increased numbers of chromogranin A-positive (+), including orexigenic ghrelin+ cells, in the stomach of calorie-restricted mice.
View Article and Find Full Text PDFCalorie restriction increases lifespan. While some tissue-specific protective effects of calorie restriction have been described, the impact of calorie restriction on the gastrointestinal tract remains unclear. We found increased abundance of chromogranin A+, including orexigenic ghrelin+, endocrine cells in the stomach of calorie-restricted mice.
View Article and Find Full Text PDFResearch on the etiology and treatment of diabetes has made substantial progress. As a result, several new classes of anti-diabetic drugs have been introduced in clinical practice. Nonetheless, the number of patients achieving glycemic control targets has not increased for the past 20 years.
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- * The study reveals that the protein TOX4, which is influenced by cAMP and dexamethasone, plays a significant role in regulating HGP independently of insulin signaling.
- * Inhibition of TOX4 leads to reduced glucose production and improved glucose tolerance, suggesting it could be an important target for addressing diabetes-related metabolic issues.
With chronic opioid use becoming an increasingly common occurrenceamong the general population, perioperative specialties must adapt to the physiologic changes caused by long-term opioids. However, data on the clinicalanesthetics implications of long-term opioid use is scarce. This review intends to survey the literature addressing the molecular mechanisms of long-term opioid use as well as their interaction with various organ systems.
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