Publications by authors named "Maria Moreno Morales"
Early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy: a multicentre double-blind pilot randomised controlled trial.
Arch Dis Child Fetal Neonatal Ed
October 2024
Objective: To examine the feasibility of early and extended erythropoietin monotherapy after hypoxic ischaemic encephalopathy (HIE).
Design: Double-blind pilot randomised controlled trial.
Setting: Eight neonatal units in South Asia.
Article Synopsis
- This study investigates the safety and effectiveness of whole-body hypothermia in neonates who have experienced mild hypoxic-ischemic encephalopathy (HIE), as existing data mainly focuses on cases of more severe illness.* -
- Conducted as a randomized clinical trial across six neonatal intensive care units in the UK and Italy, 101 eligible neonates were assigned to either normothermia or different durations of hypothermia (48 or 72 hours) based on their age after birth.* -
- The study primarily measures the concentration of thalamic N-acetyl aspartate through MRI to assess the impact of hypothermia on brain health, revealing specific outcomes in the treatment groups.*
Background: Oxytocin is widely used for induction and augmentation of labour, particularly in low- and middle-income countries (LMICs). In this systematic review and meta-analysis, we examined the effect of intra-partum Oxytocin use on neonatal encephalopathy.
Methods: The protocol for this study was registered with PROSPERO (ID: CRD42020165049).
Background: Although therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy in low-income and middle-income countries is unclear. We aimed to examine whether therapeutic hypothermia alongside optimal supportive intensive care reduces death or moderate or severe disability after neonatal encephalopathy in south Asia.
Methods: We did a multicountry open-label, randomised controlled trial in seven tertiary neonatal intensive care units in India, Sri Lanka, and Bangladesh.
Objective: We examined whether erythropoietin monotherapy improves neurodevelopmental outcomes in near-term and term infants with neonatal encephalopathy (NE) in low-middle income countries (LMICs).
Methods: We searched Pubmed, Embase, and Web of Science databases to identify studies that used erythropoietin (1500-12,500 units/kg/dose) or a derivative to treat NE.
Results: Five studies, with a total of 348 infants in LMICs, were retrieved.
Introduction: Time-critical neonatal trials in low-and-middle-income countries (LMICs) raise several ethical issues. Using a qualitative-dominant mixed-methods design, we explored informed consent process in Hypothermia for encephalopathy in low and middle-income countries (HELIX) trial conducted in India, Sri Lanka and Bangladesh.
Methods: Term infants with neonatal encephalopathy, aged less than 6 hours, were randomly allocated to cooling therapy or usual care, following informed parental consent.
Association of Total Sarnat Score with brain injury and neurodevelopmental outcomes after neonatal encephalopathy.
Arch Dis Child Fetal Neonatal Ed
November 2021
Article Synopsis
- - The study investigated how Total Sarnat Score (TSS) relates to brain injuries in newborns and their future developmental outcomes after receiving therapeutic hypothermia for neonatal encephalopathy.
- - They found significant associations between higher TSS and specific brain injuries on MR imaging and lower cognitive, motor, and language scores at 2 years old.
- - A TSS greater than 12 within the first 6 hours after birth signified a higher risk of adverse outcomes, whereas a TSS less than 4 suggested a better chance of survival and positive outcomes for the infants.