Longitudinal Analysis of Bone Metabolic Markers and Bone Mechanical Properties in STZ-Induced Diabetic Rats.

This longitudinal study examined the early effects of type 1 diabetes on bone mechanical properties and metabolic markers in mature rats, focusing on the natural progression of diabetes-induced changes without external treatments. : Forty-eight 8-month-old male Wistar rats were divided into two groups, with one group receiving a single dose of streptozotocin (STZ, 60 mg/kg). Assessments were performed 2, 4, and 8 weeks post-administration, including serum biochemical analyses, bone marker assessments, and mechanical bone tests.

Prenatal Fumonisin Exposure Impairs Bone Development via Disturbances in the OC/Leptin and RANKL/RANK/OPG Systems in Weaned Rat Offspring.

The goal of the current study was to examine the effects of prenatal exposure to fumonisins (FBs) on bone properties and metabolism in weaned rat offspring divided into groups intoxicated with FBs at either 0 (the 0 FB group), 60 (the 60 FB group), or 90 mg/kg b.w. 0 (the 90 FB group).

as a Predominant Oral Bacteria Related to the Occurrence of Dental Caries in Polish Children at 12 Years Old.

Dental caries is listed by the WHO as one of the major non-communicable diseases that need to be prevented and treated. The aim of the study was to evaluate the prevalence and severity of caries expressed as the Decayed, Missing and Filled Permanent Teeth (DMFT) index in 12-year-old Polish children and to verify bacterial species related to the occurrence of dental caries. Quantitative real-time PCR analysis of DNA isolated from saliva samples was performed to detect 8 cariogenic and periopathogenic bacterial strains.

Trabecular Bone Parameters, TIMP-2, MMP-8, MMP-13, VEGF Expression and Immunolocalization in Bone and Cartilage in Newborn Offspring Prenatally Exposed to Fumonisins.

Fumonisins are protein serine/threonine phosphatase inhibitors and potent inhibitors of sphingosine N-acyltransferase (ceramide synthase) disrupting de novo sphingolipid biosynthesis. The experiment was conducted to evaluate the effects of fumonisins (FB) exposure from the 7th day of pregnancy to parturition on offspring bone development. The rats were randomly allocated to either a control group ( = 6), not treated with FBs, or to one of the two groups intoxicated with FBs (either at 60 mg FB/kg b.

The Effects of Prenatal Supplementation with β-Hydroxy-β-Methylbutyrate and/or Alpha-Ketoglutaric Acid on the Development and Maturation of Mink Intestines Are Dependent on the Number of Pregnancies and the Sex of the Offspring.

Prenatal and postnatal supplementation with β-hydroxy-β-methylbutyrate (HMB) and alpha-ketoglutaric acid (AKG) affects the development and maturation of offspring. Both substances have the potential to stimulate cell metabolism via different routes. However, parity affects development and may alter the effects of dietary supplementation.

The Protective Role of Alpha-Ketoglutaric Acid on the Growth and Bone Development of Experimentally Induced Perinatal Growth-Retarded Piglets.

The effect of alpha-ketoglutaric acid (AKG) supplementation to experimentally-induced, perinatal growth-retarded piglets was examined. Sows were treated with a synthetic glucocorticoid (Gc) during the last 25 days of pregnancy, and after the birth, piglets were randomly divided into three groups depending on the treatment. The Gc/Gc + AKG and Gc/AKG groups born by Gc-treated sows after the birth were treated with Gc or Gc + AKG for 35 days.

Near-Surface Studies of the Changes to the Structure and Mechanical Properties of Human Enamel under the Action of Fluoride Varnish Containing CPP-ACP Compound.

Changes to the features of the enamel surface submitted to induced demineralisation and subsequent remineralisation were studied. The in vitro examination was conducted on polished slices of human molar teeth, divided in four groups: the untreated control ( = 20), challenged by a demineralisation with orthophosphoric acid (HPO) ( = 20), and challenged by a demineralisation following remineralisation with fluoride (F) varnish containing casein phosphopeptides (CPP) and amorphous calcium phosphate (ACP) compounds ( = 20). The specimens' enamel surfaces were subjected to analysis of structure, molecular arrangement, mechanical features, chemical composition, and crystalline organization of apatite crystals.

Chronic dietary supplementation with kynurenic acid, a neuroactive metabolite of tryptophan, decreased body weight without negative influence on densitometry and mandibular bone biomechanical endurance in young rats.

Kynurenic acid (KYNA) is a neuroactive metabolite of tryptophan. KYNA naturally occurs in breast milk and its content increases with lactation, indicating the role of neonatal nutrition in general growth with long-term health effects. KYNA is also an antagonist of ionotropic glutamate receptors expressed in bone cells.

Surface analysis of etched enamel modified during the prenatal period.

Structural changes in the enamel surface subjected to induced demineralization and assessment of the influence of prenatal administration of β-hydroxy β-methylbutyrate (HMB) on enamel resistance were investigated. The examination was conducted on five sets of teeth from one-day-old spiny mice (Acomys cahirinus), one from the control and four from the experimental groups. Surface structure, molecular arrangement and crystalline organization of offspring's enamel both before and after etching were studied.

Entamoeba gingivalis - prevalence and correlation with dental caries in children from rural and urban regions of Lublin Province, Eastern Poland.

Introduction: , as the name implies. typically lives around the gumline of the teeth in the tartar and gingival pockets of the oral cavity. Pathogenicity of protozoa in the oral cavity is not completely understood.

Problems with access to dental treatment for children with epilepsy.

Introduction: Epilepsy is a common medical disorder and due to a variety of barriers, people with epilepsy may not have access to needed healthcare services, particularly based on their place of residence.

Objectives: The aim of the study was to assess access to dental treatment in children and adolescents with epilepsy in Lublin Voivodeship.

Material And Methods: Clinical and questionnaire examinations were performed in 107 children and young people, of both sexes, in the ages between 6 and 18years old from the Lublin macroregion.

Evaluation of oral cavity condition with regard to decay in 18-year old from urban and rural areas in Podkarpackie Province, Poland.

Introduction: The studies have indicated the necessity to intensify dental health care in certain Polish provinces. The purpose of study was to evaluate dental condition and establish dental health needs in the population of 18-year old youth from urban and rural region in Podkarpackie Province, Poland.

Material And Method: Mean DMFT index (D-decayed, M-missing and F-filled teeth) was calculated as a key measure of dental decay and dental health needs identified.

An Assessment of the Number of Cariogenic Bacteria in the Saliva of Children with Chemotherapy-Induced Neutropenia.

Background: Anticancer therapy entails qualitative and quantitative changes in the physiological bacterial flora of the organism, including the oral microflora.

Objectives: The aim of the study was to assess the number of cariogenic bacteria - Streptococcus mutans and Lactobacillus spp. - in the saliva of children with chemotherapy-induced neutropenia, and the relationship between the dynamics of neutrophils in the blood and the number of cariogenic bacteria in the saliva.

Life style and risk of development of dental caries in a population of adolescents.

Introduction: Oxygen is an essential element for sustaining the life of aerobes; however, in certain conditions it may be toxic for these organisms. This is due to so-called reactive oxygen species - ROS. Factors which cause the production of free radicals include ionizing radiation, UV radiation, high temperature, and hazardous substances, such as phenols, carbon monoxide, e.

Passive smoking as an environmental health risk factor.

Initially, tobacco was considered as a decorative plant and only later began to be treated as a herb with special therapeutic properties. With time, it was found that tobacco had strong insecticidal and addictive properties. There also occurred reports about the negative influence of tobacco on human health.

Oral hygiene in children suffering from acute lymphoblastic leukemia living in rural and urban regions.

Introduction And Objective: During acute lymphoblastic leukemia treatment, oral mucositis is a hugely important dental problem. In order to lower the risk of such complications, patients should take special care of their oral hygiene. The aim of this study was to assess the oral hygiene status in children with ALL during anti-cancer treatment protocols.

Smoking and the level of nicotine addiction in relation to the state of hard dental tissues in young adults.

Nowadays, smoking is considered to be one of the unhealthiest human behaviours. The aim of this study was to evaluate the potential influence of smoking, as well as the degree of the addiction, on the health status of hard dental tissues in young adults. The study involved 148 randomly selected young adults.

Duchenne muscular dystrophy--a dental healthcare program.

Duchenne muscular dystrophy (DMD) is a genetically determined disease. The chief characteristic of this clinical syndrome is a progressive degeneration of particular groups of muscles. Initially there is physical impairment, contractures, and muscular atrophy.

Dental problems in epileptic patients.

On the grounds of literature and own clinical experience, pathological changes in epilepitic patients have been described. Dental management procedures in these patients have also been presented. The unquestionable importance of prophylaxis, which may markedly minimize the impact of epilepsy on the incidence of mouth diseases, has been emphasised.

The methods of treating deciduous dentition after mechanical traumas.

For the sake of very young patients and the processes of growth and development of the masticatory system they undergo, mechanical traumas of deciduous teeth require immediate treatment. The choice of treatment method of the deciduous dentition traumas depends on a type of sustained injury, the developmental stage of deciduous teeth and first of all on a child's ability to cooperate. The primary objective of the therapeutic management is to retain the physiological function of an injured tooth and to protect the regular development of a permanent tooth bud.

Occurrence of non-carious enamelopathies in the children living in the vicinity of the Coal Mine Bogdanka.

The main aim of this study was to examine the incidence of enamelopathies among children from the Bogdanka region. Altogether, there were examined 273 people (aged 7-14) who live in the neigbourhood of the mainfield (group I). The controlled group consisted of 188 children of the same age who lived in the areas free of chemical pollution (group II).

The outcome of implementation of a dental prophylactics programme among eleven-year-old children from the Lublin region.

The aim of this study was evaluation of effectiveness of a professional carious disease prevention programme implemented in the Lublin region for a group of 11-year-old children at high risk of caries. On the basis of clinical dental examination a group of children at high risk of caries was selected (yearly increase in the number of new active caries foci of 4 and more--mean D value of 5.66), in whom therapeutic and prophylactic procedures comprising the caries prevention programme were performed.

Evaluation of the masticatory system condition with respect to the need for prosthetic treatment in the population of 35-44-year-olds from the Lublin Region.

An epidemiological study was carried out on the population of 59 subjects aged 35-4 (30 women, 29 men) living in Lublin. An evaluation of dentition status and degree of provision for prosthetic needs was done. We observed a remarkable frequency of dental caries, a large percentage of subjects with missing or damaged teeth (76.

Evaluation of stomatological needs of 8-year-old children connected with premature loss of deciduous teeth.

The study covered 106 eight-year-old children attending different schools in Lublin that do not provide dental care. The study evaluated decay frequency, DEF value and its components D, E, F, def value and its components d, e, f as well as treatment index for deciduous and permanent teeth. Additionally, it assessed the needs for orthodontic and prosthetic provisions connected with premature loss of deciduous teeth.