Publications by authors named "Maria M Khaydukova"
The C3f peptide is a by-product of regulation of the activated complement system with no firmly established function of its own. We have previously shown that C3f exhibits moderate antimicrobial activity against some Gram-positive bacteria . Presence of two histidine residues in the amino acid sequence of the peptide suggests enhancement of its antimicrobial activity at lower pH and in the presence of metal cations, particularly zinc cations.
View Article and Find Full Text PDFArticle Synopsis
- - Innate immunity in invertebrates provides effective antimicrobial peptides (AMPs) that combat drug-resistant infections, sparking interest in finding new β-hairpin AMPs from worm proteins with a BRICHOS domain.
- - Researchers discovered new BRICHOS AMPs from caecilians, a lesser-known group of vertebrates, revealing similarities to lung surfactants and suggesting a unique lung function.
- - The identified peptides show strong antibacterial properties against multidrug-resistant ESKAPE pathogens while being low in toxicity, indicating potential as a new antibiotic model and highlighting a previously unrecognized lung immunity mechanism.