Publications by authors named "Maria Lusia Moras"
Article Synopsis
- The study focused on ITF2357, a synthetic inhibitor of histone deacetylases (HDACs), which can enhance gene expression by unraveling chromatin and is being evaluated for its anti-inflammatory properties.
- ITF2357 significantly reduced the release of pro-inflammatory cytokines such as TNFalpha and IFNgamma in lab-cultured human blood cells, while showing no effect on IL-8 levels and not causing cell death.
- In experiments with mice, oral doses of ITF2357 lowered TNFalpha and IFNgamma levels in serum and helped reduce liver damage from hepatitis without affecting other induced cytokines, indicating its potential as an anti-inflammatory agent.
