Publications by authors named "Maria Luiza Froes da Motta Dacome"
Future Microbiol
October 2024
Article Synopsis
- - The study evaluated a new hybrid compound derived from oxadiazol-4-methoxynaphthalene for its potential to inhibit a specific virus and clinical isolates, alongside its interaction with anti-tuberculosis drugs.
- - Researchers determined the minimal inhibitory concentration, conducted time kill curve assays, and assessed pharmacokinetics and cytotoxicity to understand the effectiveness and safety of the compound.
- - The findings suggest that the newly synthesized molecule shows promising anti-viral activity with low toxicity, making it a candidate for further development as an anti-TB drug.
Tuberculosis (Edinb)
September 2024
Article Synopsis
- This study focused on synthesizing 22 salicylhydrazone derivatives to test their effectiveness as new anti-TB drugs in vitro.
- Three compounds (10, 11, and 18) were highlighted for their promising results, with compound 18 showcasing the best activity against Mycobacterium tuberculosis at a low MIC of 0.49 μg/mL and good safety profile.
- The compounds exhibited cooperative effects when tested with existing TB drugs and showed potential against both drug-susceptible and resistant strains, particularly compound 18 which stood out due to its low cytotoxicity.
