As soon as possible in IgE-cow's milk allergy immunotherapy.

Oral immunotherapy is a common treatment in cow's milk protein allergy. The Department of Pediatric Allergology at the Children's Hospital of Zaragoza performed a retrospective analysis of 335 infants under 1 year of age diagnosed with IgE-mediated cow's milk and early treated. Clinical evaluation, skin prick test, and serum-specific IgE level control were performed before starting and after finishing treatment.

[Natural progression of premature pubarche and underlying diseases].

Introduction: Premature pubarche (PP) is generally thought to be a benign condition, but it can also be the first sign of underlying disease.

Objective: To analyse the aetiology and the evolution of the anthropometric, analytical and metabolic risk parameters of a group of patients with PP.

Material And Methods: A descriptive and analytical retrospective study of 92 patients affected by PP.