Cerebrospinal fluid impairs antimicrobial activity of fosfomycin in vitro.

Objectives: Fosfomycin penetrates well into cerebrospinal fluid (CSF) and is considered for treatment of infections of the central nervous system (CNS). This study evaluated the influence of human CSF on the antimicrobial activity of fosfomycin.

Methods: Time-kill curves were performed in Mueller-Hinton broth (MHB) and in pooled human CSF using fosfomycin concentrations ranging from 0.

Antimicrobial activity of cefepime and rifampicin in cerebrospinal fluid in vitro.

Objectives: Though used for infections of the central nervous system, the pharmacodynamics of antimicrobial agents is commonly evaluated only in commercially available bacterial growth media. In the present study, the effects of cerebrospinal fluid (CSF) on bacterial killing by cefepime and rifampicin were investigated.

Methods: CSF was collected from patients who did not receive antibiotics.