Early hematopoietic stem cell transplantation in a patient with severe mucopolysaccharidosis II: A 7 years follow-up.

Mucopolysaccharidosis type II (MPS II - Hunter syndrome) is an X-linked lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2 sulfatase (I2S), leading to the accumulation of the glycosaminoglycans, affecting multiple organs and systems. Enzyme replacement therapy does not cross the blood brain barrier, limiting results in neurological forms of the disease. Another option of treatment for severe MPS, hematopoietic stem cell transplantation (HSCT) has become the treatment of choice for the severe form of MPS type I, since it can preserve neurocognition when performed early in the course of the disease.

Rabies diagnosis and serology in bats from the State of São Paulo, Brazil.

Introduction: Bats are one of the most important reservoirs and vectors of the rabies virus in the world.

Methods: From 1988 to 2003, the Zoonosis Control Center in São Paulo City performed rabies diagnosis on 5,670 bats by direct immunofluorescent test and mouse inoculation test. Blood samples were collected from 1,618 bats and the sera were analyzed using the rapid fluorescent focus inhibition test to confirm rabies antibodies.

Human and canine leptospirosis: serological data of São Paulo City, Brazil, 2000 to 2003.

Sera from humans and dogs were tested by microscopic agglutination test. Icterohaemorrhagiae was the predominant serogroup in both groups, associated with the infestation of Rattus norvegicus.