Publications by authors named "Maria Loreto Spencer"
Article Synopsis
- Tobacco use is a major risk factor for lung cancer, but 10-20% of lung cancer patients are never-smokers, with distinct clinical and genomic differences observed between smokers and never-smokers, especially in Chile.
- This study examines genomic alterations in lung cancer between smokers and never-smokers, focusing on 10 relevant genes, revealing a higher overall frequency of genetic alterations in never-smokers (58%) compared to smokers (45.7%).
- Key findings include that never-smokers tend to have higher alterations in genes like EGFR and PIK3CA, while smokers showcase a more complex genomic profile, particularly with KRAS mutations.
Background: Actinic cheilitis (AC) is characterized by epithelial and connective tissue alterations caused by ultraviolet sunlight overexposure known as photodamage. Fibroblasts have been linked to photodamage and tumor progression during skin carcinogenesis; however, their role in early lip carcinogenesis remains unknown. The aim of this study was to assess the density of fibroblasts in AC and normal lip (NL) samples and determine their association with markers of lip photodamage.
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