Sodium Hyaluronate-Induced Ocular Hypertension in Rats Damages the Direction-Selective Circuit and Inner/Outer Retinal Plexiform Layers.

Purpose: To assess the changes in retinal morphology in a rat model of chronic glaucoma induced by ocular hypertension.

Methods: Intraocular pressure (IOP) was surgically increased through weekly injections of sodium hyaluronate (HYA) in the anterior eye chamber of the left eye of male Wistar rats, whereas the right eyes were sham operated (salt solution). During the 10-week experimental period, IOP was measured weekly with a rebound tonometer.

The influence of storage method on the transparency of pig crystalline lens.

Purpose: The porcine eye is frequently used as a research model. This paper analyzes the effect of different storage methods on the transparency of pig crystalline lens.

Methods: A spectral transmission curve (from 220 to 780 nm) for the crystalline lens was determined experimentally after storage in different conditions: saline solution, formalin, castor oil, and freezing at -80°C.

Effects of intravenous administration of dexmedetomidine on intraocular pressure and pupil size in clinically normal dogs.

Objective: To evaluate the effects of the intravenous administration of dexmedetomidine on the intraocular pressure (IOP) and pupil size (PS) in normal dogs.

Animals Studied: Forty-two animals with no ocular abnormalities were included in this study.

Procedure: Following initial readings (T(0)) of IOP and PS, the dogs received an intravenous injection of dexmedetomidine (5 μg/kg).