Publications by authors named "Maria Laura Rojas"
Mitochondrial network architecture plays a critical role in cellular physiology. Indeed, alterations in the shape of mitochondria upon exposure to cellular stress can cause the dysfunction of these organelles. In this scenario, mitochondrial dynamics proteins and the phospholipid composition of the mitochondrial membrane are key for fine-tuning the modulation of mitochondrial architecture.
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- StarD7 is part of the START protein family, involved in lipid transport and cellular signaling, and its isoforms play different roles in cell function.
- Silencing StarD7 reduces the expression of key proteins (Cx43, integrin β1, and p-ERK1/2) in non-cancerous migrating cells and disrupts their cellular structures.
- Restoring Cx43 levels can regain cell migration abilities, while expressing the StarD7.II isoform enhances migration and the levels of the aforementioned proteins, indicating StarD7's role in cell migration is linked to an ERK1/2/Cx43 pathway.
Introduction: Villous cytotrophoblast (vCTB) cells fuse to generate and maintain the syncytiotrophoblast layer required for placental development and function. Krüppel-like factor 6 (KLF6) is a ubiquitous transcription factor with an N-terminal acidic transactivation domain and a C-terminal zinc finger DNA-binding domain. KLF6 is highly expressed in placenta, and it is required for proper placental development.
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