Publications by authors named "Maria Lamanna"
Background: Monoaminergic network dysfunction may have a role in multiple sclerosis (MS) fatigue pathogenesis.
Objective: To investigate modifications of fatigue severity and resting state (RS) functional connectivity (FC) in monoaminergic networks of 45 fatigued MS patients after different symptomatic treatments.
Methods: Patients were randomly, blindly assigned to fampridine (n = 15), amantadine (n = 15) or placebo (n = 15) treatment and underwent clinical and 3T-MRI evaluations at baseline (t0) and week 4 (w4), i.
Article Synopsis
- COVID-19 can lead to acute respiratory distress syndrome, requiring ICU admission and invasive ventilation, which increases the risk of ventilator-associated pneumonia (VAP) in these patients.
- A study of 284 ICU patients with COVID-19 found a 33% incidence of VAP, predominantly caused by Pseudomonas aeruginosa and Klebsiella spp., with significant antimicrobial resistance noted in these bacteria.
- Key risk factors for developing VAP included receiving blood transfusions and certain therapies, with higher VAP rates linked to orotracheal intubation compared to tracheostomy, although patient positioning and specific admission ratios did not correlate significantly with VAP incidence.
Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital.
Int J Infect Dis
April 2021
Article Synopsis
- The study analyzed COVID-19 patients in a hospital in Italy to explore factors influencing prolonged SARS-CoV-2 RNA shedding and viral clearance.
- It found that patients with comorbidities, lymphopenia, or moderate/severe respiratory issues had lower chances of viral clearance, with a median viral shedding duration of 18 days.
- Achieving viral clearance significantly improved clinical recovery rates and reduced the risk of death or the need for mechanical ventilation, emphasizing the necessity for timely hospital admission for symptomatic patients.
Objective: To date, there is no universal consensus on which is the optimal ultrastaging protocol for sentinel lymph node (SLN) evaluation in gynecologic malignancies. To estimate the impact of different ultrastaging methods of SLNs on the detection of patients with nodal metastases in early-stage cervical and endometrial cancers and to describe the incidence of low-volume metastases between two ultrastaging protocols.
Methods: We retrospectively compared two ultrastaging protocols (ultrastaging-A vs ultrastaging-B) in patients with clinical stage I endometrial cancer or FIGO stage IA-IB1 cervical cancer who underwent primary surgery including SLN biopsy from October 2010 to December 2017 in our institution.
Standard ultra-staging compared to one-step nucleic acid amplification for the detection of sentinel lymph node metastasis in endometrial cancer patients: a retrospective cohort comparison.
Int J Gynecol Cancer
March 2020
Introduction: The objective of this study was to compared standard ultra-staging (SU) with one-step nucleic acid amplification (OSNA) for the detection of sentinel lymph node (SLN) metastasis in women with apparent uterine-confined endometrial cancer.
Methods: All women underwent SLN identification with complete surgical staging. All SLNs were cut perpendicular to the long axis and two adjacent 5 µm sections were cut at each of two levels 50 µm apart.
Introduction: F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is a diagnostic tool widely used in oncology, but to date there are no established recommendations for its use in malignant ovarian germ cell tumors. The aim of this study was to evaluate the role of F-FDG PET/CT in the clinical management of patients with malignant ovarian germ cell tumors.
Methods: This was a retrospective review of F-FDG PET/CT scans performed in patients diagnosed with malignant ovarian germ cell tumors treated at the gynecology department of San Gerardo Hospital (Monza, Italy) from June 2006 to December 2016.
Background: Even if borderline ovarian tumours (BOTs) in young women treated with fertility-sparing treatment (FST) have an excellent outcome, the type of surgery might affect relapse and fertility. We investigated the effect of surgical approach (open surgery vs. laparoscopy) and type of surgery (salpingo-oophorectomy [SO] vs.
View Article and Find Full Text PDFBackground: The effect of chemotherapy exposure (CE) on ovarian function in young women with ovarian neoplasms undergoing fertility-sparing treatment (FST) remains unclear. We investigated whether CE is correlated with the outcomes (1) during-treatment and (2) post-treatment amenorrhea, (3) conception rate, (4) pregnancy outcome, and (5) spontaneous menopausal age.
Patients And Methods: Eligibility criteria were patients with a diagnosis of epithelial (EOC) or nonepithelial (no-EOC) invasive ovarian neoplasm, premenopausal age, undergoing FST ± CE, histopathology confirmation, and adequate follow-up.
The impact of the type of nodal assessment on prognosis in patients with high-intermediate and high-risk ESMO/ESGO/ESTRO group endometrial cancer. A multicenter Italian study.
Eur J Surg Oncol
October 2018
Objectives: The majority of endometrial cancers (EC) are discovered while the disease is confined to the uterine body. The presence of lymph nodes metastases impairs the prognosis. In this study, we evaluated the possible impact on survival of sentinel lymph node (SLN) mapping algorithm and selective lymphadenectomy (LD) in early stage EC, according to the ESMO-ESGO-ESTRO risk subgroup classification.
View Article and Find Full Text PDFObjective: The aim of the present study was to assess, in a population of dichorionic twin pregnancies with selective growth restriction, the effect of inter-twin differences by use of Doppler velocimetry and fetal growth discordancy on perinatal outcomes.
Methods: This was a retrospective study including dichorionic twin pregnancies from January 2008 to December 2015 at the Department of Obstetrics and Gynecology of Fondazione MBBM. Only dichorionic twin pregnancies affected by selective intrauterine growth restriction (IUGR) delivering at ≥24 weeks were included in the study.