Publications by authors named "Maria L Pierelli"
Nucleic Acids Res
April 2024
Article Synopsis
- A subset of circular RNAs (circRNAs) and linear RNAs can block microRNA activity, with some RNAs leading to microRNA degradation via a process called Target RNA-Directed MicroRNA Degradation (TDMD).
- In this study, researchers explored how the shape (circular vs. linear) of RNA targets impacts TDMD, finding that the circular RNA Cdr1as protects the microRNA miR-7, while an artificial linear version promotes its degradation.
- The findings suggest that RNA circularity significantly affects TDMD dynamics, influencing the stability and activity of specific microRNAs beyond just their nucleotide sequences.
