Glutamine promotes human CD8 T cells and counteracts imiquimod-induced T cell hyporesponsiveness.

T cells protect tissues from cancer. Although investigations in mice showed that amino acids (AA) critically regulate T cell immunity, this remains poorly understood in humans. Here, we describe the AA composition of interstitial fluids in keratinocyte-derived skin cancers (KDSCs) and study the effect of AA on T cells using models of primary human cells and tissues.

Gender and social protection and health policies promoted during the COVID-19 pandemic: Global scoping review and future challenges.

Background: Governmental interventions have been important tools for mitigating COVID-19 transmission, but they have also negatively impacted different gender-related components. We aimed to answer the following questions: What is the scope of the gender approach in the literature analysing health and social protection policies promoted during the COVID-19 pandemic? What are the challenges and recommendations for gender-sensitive policies for the post-pandemic and future crises?

Methods: The study design is based on three stages: a global synthesis of the evidence through a scoping review, the generation of a framework of emerging inequalities based on sociocultural markers, and the creation of a matrix with the challenges and recommendations. In this scoping review, we searched 10 online databases for studies published until April 2022 and conducted a content analysis on the extracted studies.

Effect of a home-based inspiratory muscle training programme on functional capacity in postdischarged patients with long COVID: the InsCOVID trial.

Background: Fatigue and exercise intolerance are the most common symptoms in patients with long COVID.

Aims: This study aimed to evaluate whether a home-based inspiratory muscle training (IMT) programme improves maximal functional capacity in patients' long COVID after a previous admission due to SARS-CoV-2 pneumonia.

Methods: This study was a single-centre, blinded assessor, randomised controlled trial.

Middle Stone Age Bifacial Technology and Pressure Flaking at the MIS 3 Site of Toumboura III, Eastern Senegal.

Unlabelled: Over the past decade, the increasing wealth of new archaeological data on the Middle Stone Age (MSA) in Senegal and Mali has broadened our understanding of West Africa's contributions to cultural developments. Within the West African sequence, the phase of Marine Isotope Stage 3 (MIS 3, ca. 59-24 ka) yielded so far the best known and extensive archaeological information.

Engagement in migrant organizations for immigrant integration: A mixed-method study with Peruvians in Chile.

Immigrant communities in Chile face barriers to their integration, in the form of discrimination and social exclusion. Psychology of liberation claims that, when minority groups experience oppressing conditions, community engagement can be a path toward integration. Nevertheless, community participation has been mainly studied in North America and Europe.

Environmental variables affecting an arid coastal nebkha.

Foredunes in arid coastal dune systems comprise nebkhas, which originate by interactions between vegetation and aeolian sedimentation. While continuous foredunes in temperate climates have been widely studied, knowledge of interactions between biotic and abiotic drivers in foredunes formed by nebkha is still scarce. With the aim of exploring variables affecting arid foredunes, a range of morphological, sedimentological, and vegetation characteristics were measured on a single nebkha formed by a Traganum moquinii plant located in the foredune of Caleta de Famara beach (Lanzarote, Canary Islands).

Methotrexate Ameliorates Systemic Inflammation and Septic Associated-Lung Damage in a Cecal Ligation and Puncture Septic Rat Model.

Background: Sepsis is a serious, heterogeneous clinical entity produced by a severe and systemic host inflammatory response to infection. Methotrexate (MTX) is a folate-antagonist that induces the generation of adenosine and also inhibits JAK/STAT pathway; MTX it is widely used as an anti-inflammatory drug to control the immune system.

Objective: The aim of this study was to assess the beneficial effects of a single and low dose of MTX in the systemic response and acute lung injury (ALI) induced by sepsis.

Comparison of biomarker responses after acute and chronic bioassays in Lumbriculus variegatus.

Differential biomarker responses may occur after acute or chronic bioassays when animals are unfed. In many aquatic species, food deprivation may lead to a pro-oxidant condition. However, information about its effects on the oligochaete Lumbriculus variegatus, a bioindicator organism for water and sediment toxicity tests, is almost completely lacking.

[Validation of a high sensitive troponin 99th percentile obtained in a general hospital].

Introduction: High sensitivity cardiac Troponin T (hs-cTnT) dosage is recommended for myocardial infarction diagnosis, by applying the 99th percentile obtained from a healthy population by the manufacturer. The objective is to validate the 99th percentile in a population from our hospital (99L), compared with the manufacturer´s 99th percentile (99F) by using coronary angiography as gold standard.

Materials And Methods: Retrospective analysis of every hs-cTnT (Roche) obtained from patients admitted with acute coronary syndromes (ACS) who underwent coronary angiography between 2015 and 2018.

An approach to antibiotic treatment in patients with sepsis.

Sepsis is a medical emergency and life-threatening condition due to a dysregulated host response to infection, which is time-dependent and associated with unacceptably high mortality. Thus, when treating suspicious or confirmed cases of sepsis, clinicians must initiate broad-spectrum antimicrobials within the first hour of diagnosis. Optimizing antibiotic use is essential to ensure successful outcomes and to reduce adverse antibiotic effects, as well as preventing drug resistance.

Anatomical and Biochemical Changes Induced by Stand Up for Seedlings From Infection.

Nowadays, fertilization and pest control are carried out using chemical compounds that contaminate soil and deteriorate human health. Plant growth promoting bacteria endophytes (PGPBEs), are a well-studied group of bacteria that offers benefits to the host plant, such as phytostimulation, biofertilization, and protection against other microorganisms. The study of -which belongs to PGPBEs-aids the development of alternative strategies of an integrated approach for crop management practices.

[Effectiveness of transthoracic echocardiogram in patent foramen ovale diagnosis. Systematic review of last ten years.].

Background: Transesophageal echo (TEE) bubble study is the current gold standard for patent foramen ovale (PFO) diagnosis, but it has the disadvantage of being semi-invasive and not exempted from risks. The aim of this study was to determine the accuracy of TTE compared to TEE for PFO diagnosis.

Methods And Results: a systematic review was done on Medline with the terms "transthoracic echocardiography, transesophageal echocardiography, patent foramen ovale, diagnosis" yielding published literature of the last ten years.

Family Communication and Verbal Child-to-Parent Violence among Adolescents: The Mediating Role of Perceived Stress.

In recent years, there has been an increase in the number of reported incidents of child-to-parent violence (CPV); however, this type of intra-family violence remains vastly understudied compared with other forms of family violence. The aim of this study is to analyze the relationship between family communication and verbal CPV through the mediation of adolescent perceived stress. The sample consisted of 2399 Spanish students of both genders between the ages of 11 and 20 years.

Cross-national evidences of a school-based universal programme for promoting prosocial behaviours in peer interactions: Main theoretical communalities and local unicity.

The purpose of this study was to evaluate the role of prosocial behaviour against aggression in a school-based universal intervention adapted in two different (non-Western) countries, Colombia and Chile. Using a randomised pretest-post-test design (and controlling for participants' gender and parents' level of education), current results highlighted different effects of a similar programme in both sites. First, the school-based universal programme designed for promoting prosocial behaviours in the peer context obtained a positive cross-national effect on prosocial behaviour rated by three informants (i.

Ga-SBA-3 A novel nanostructured material: synthesis, characterization and application.

This paper reports for the first time the incorporation of gallium into the structure of the mesoporous SBA-3 material in order to modify the intrinsic acidity of the material. The study indicates the effective incorporation of Ga into a network in tetrahedral form, with most in the interior of the lodging and a low proportion on the external surface. Gallium was introduced via post-synthesis using Ga-nitrate in appropriate conditions.

Impact of hemoperfusion with polymyxin B added to hemofiltration in patients with endotoxic shock: a case-control study.

Background: Septic shock is a leading cause of death in critical patients. In patients with gram-negative septic shock, hemoperfusion with polymyxin B aims to remove endotoxins from plasma. We analyzed the clinical and biological response to hemoperfusion in patients with septic shock and acute kidney injury.

Improved empirical antibiotic treatment of sepsis after an educational intervention: the ABISS-Edusepsis study.

Background: Early appropriate antibiotic treatment is essential in sepsis. We aimed to evaluate the impact of a multifaceted educational intervention to improve antibiotic treatment. We hypothesized that the intervention would hasten and improve the appropriateness of empirical antibiotic administration, favor de-escalation, and decrease mortality.

Probing the Catalytic Activity of Sulfate-Derived Pristine and Post-Treated Porous TiO(101) Anatase Mesocrystals by the Oxidative Desulfurization of Dibenzothiophenes.

Mesocrystals (basically nanostructures showing alignment of nanocrystals well beyond crystal size) are attracting considerable attention for modeling and optimization of functionalities. However, for surface-driven applications (heterogeneous catalysis), only those mesocrystals with excellent textural properties are expected to fulfill their potential. This is especially true for oxidative desulfuration of dibenzothiophenes (hard to desulfurize organosulfur compounds found in fossil fuels).

Tributyltin bioaccumulation and toxic effects in freshwater gastropods Pomacea canaliculata after a chronic exposure: field and laboratory studies.

Freshwater samples and gastropod mollusks (Pomacea canaliculata) were collected at 5 sampling stations located along the lower Río de la Plata basin, Argentina, to assess the extent of tributyltin (TBT) contamination. Determined data revealed the presence of TBT and some of its breakdown products (dibutyltin: DBT, and monobutyltin: MBT) in all freshwater samples and also in soft tissues of P. canaliculata gastropods.

Impact of Source Control in Patients With Severe Sepsis and Septic Shock.

Objectives: Time to clearance of pathogens is probably critical to outcome in septic shock. Current guidelines recommend intervention for source control within 12 hours after diagnosis. We aimed to determine the epidemiology of source control in the management of sepsis and to analyze the impact of timing to source control on mortality.

Unchanged Levels of Soluble CD14 and IL-6 Over Time Predict Serious Non-AIDS Events in HIV-1-Infected People.

HIV-1-infected persons have increased risk of serious non-AIDS events (SNAEs) despite suppressive antiretroviral therapy. Increased circulating levels of soluble CD14 (sCD14), soluble CD163 (sCD163), and interleukin-6 (IL-6) at a single time point have been associated with SNAEs. However, whether changes in these biomarker levels predict SNAEs in HIV-1-infected persons is unknown.

[Infant Mortality in Argentina: reducibility criteria, 3rd review].

The infant mortality rate is an indicator of quality of life, development, and quality and accessibility of health care. Improvements in science, technology and better access to health care have contributed to a major decrease in the infant mortality rate in Argentina. Since the 1980s, infant deaths have been classified based on the opportunities for reducibility yielded by scientific knowledge and available technologies, in order to obtain a basis for the monitoring and implementation of health policies.

Clinical impact of stress dose steroids in patients with septic shock: insights from the PROWESS-Shock trial.

Introduction: The aim of our study was to evaluate the clinical impact of the administration of intravenous steroids, alone or in conjunction with drotrecogin-alfa (activated) (DrotAA), on the outcomes in septic shock patients.

Methods: We performed a sub-study of the PROWESS-Shock trial (septic shock patients who received fluids and vasopressors above a predefined threshold for at least 4 hours were randomized to receive either DrotAA or placebo for 96 hours). A propensity score for the administration of intravenous steroids for septic shock at baseline was constructed using multivariable logistic regression.

Efficacy and acceptability of a mifepristone-misoprostol combined regimen for early induced abortion among women in Mexico City.

Objective: To evaluate the experience of women receiving mifepristone-misoprostol for early induced abortion in public sector facilities in the Federal District of Mexico City.

Methods: An open-label prospective study was conducted with 1000 pregnant women who sought induced abortion with a pregnancy of up to 63days of gestation, as measured from the date of their last menstrual period. The study was conducted in three public sector healthcare facilities: two secondary level hospitals and one primary care clinic.