Cognitive and motor functioning in a patient with selective infarction of the left basal ganglia: evidence for decreased non-routine response selection and performance.

Focal damage to the basal ganglia is relatively rare, and little is known about the cognitive effects of damage to specific basal ganglia structures. A 28-year-old, highly educated male (patient RI) sustained a unilateral left ischemic infarction involving primarily the putamen and secondarily the head of the caudate and the anterior internal capsule. Two detailed neuropsychological assessments, at 3 and 16 months post-infarction, revealed that a majority of cognitive abilities were spared.

Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control.

We examine the hypothesis that the efficiency of executive control processes is less stable over time in older than younger adults. An age-related decrease in the efficiency of executive control should result in an increase in performance variability in task conditions requiring the recruitment of executive control processes and not in task conditions requiring minimal involvement of executive control. Performance variability was similar for younger and older adults in task conditions requiring minimal executive control and greater for older than younger adults in task conditions requiring executive control.

Effects of time of day on age differences in working memory.

This study investigated the hypothesis that the influence of time of day on the efficiency of working memory is greater for older than younger adults. Groups of younger and older adults performed a working memory task on 4 consecutive days, twice in the morning and twice in the evening. Objective (body temperature) and subjective (alertness ratings) measures of arousal were taken during each session.