[Evaluation of some selected structural and functional parameters of red blood cells as oxidative stress markers in elderly people with primary hypertension].

Unlabelled: The aim of the study was to evaluate the degree of membrane lipid peroxidation, internal microviscosity, activity of both total and Na+, K+ membrane ATP-ase and markers of oxidative damage of membrane protein in erythrocytes of elderly people with primary hypertension.

Material And Methods: The examination was performed on 50 people. The first group (HA) consisted of 15 elderly people with primary hypertension (mean age 71, 3 years old).

[The influence of Q10 coenzyme on structural and functional parameters of red blood cells in elderly people].

Unlabelled: The free radical theory of aging assumes that aging process leads to lost of oxidative balance. Oxidative stress induces structural and functional changes in red blood cell. The Q10 coenzyme is known as a compound which may partially prevent those changes in erythrocytes, due to its antioxidative properties and the important role it plays in the cell.

Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia.

Background: Hypercholesterolemia may decrease the deformability of red blood cells which impairs their hemorheological behavior and promotes atherosclerosis. The study involved 60 hypercholesterolemic patients and 30 healthy individuals as the control group.

Methods: The membrane fluidity of erythrocytes was estimated by a spin-label method (5-doxylstearic acid (5-DSA)).

Effects of simvastatin and pravastatin on peroxidation of erythrocyte plasma membrane lipids in patients with type 2 hypercholesterolemia.

Since hypercholesterolemia directly modifies the composition of erythrocytes plasma membrane, the influence of statins on erythrocytes has been researched. The beneficial effects of statins on clinical events may involve mechanisms that modify endothelial dysfunction, plaque stability, thrombus formation and inflammatory responses. The aim of the study was to evaluate the hypolipemic efficacy and effects of pravastatin and simvastatin on erythrocyte membrane fluidity and damage of erythrocytes in patients with type 2 hypercholesterolemia in comparison with a control group of healthy subjects.

Induction and decay of thermotolerance in human erythrocytes determined by hemolysis.

Hemolysis was used as an endpoint for the measurement of damage to the plasma membrane in human erythrocytes after a single or a double heat shock. The thermotolerance of erythrocytes is a transitional phenomenon, reaching its maximum at a 3-hour incubation at 37 degrees C between the heat shocks.

Damage to the erythrocyte membrane caused by chlorophenoxyacetic herbicides.

We studied the damage caused to erythrocyte membranes by chlorophenoxyacetic herbicides. An increase in haemolysis was observed. The compounds investigated caused lipid bilayer damage by lipid peroxidation, as well as an increase in membrane fluidity at the 16th carbon atom of fatty acids was observed.