A new generation of 1,8-diaminocarbazole building blocks for the construction of fluorescent anion receptors.

We describe the synthesis of a new generation of 1,8-diaminocarbazole building blocks for the construction of anion receptors and fluorescent sensors. These new building blocks feature mildly electron-withdrawing ester substituents at positions 3 and 6 of the carbazole core, which improve anion affinities and significantly enhance solubilities, without compromising fluorescent response. To demonstrate the advantages of the new building blocks, three of them were converted into model diamide receptors R1-R3.

Boosting Anion Transport Activity of Diamidocarbazoles by Electron Withdrawing Substituents.

Artificial chloride transporters have been intensely investigated in view of their potential medicinal applications. Recently, we have established 1,8-diamidocarbazoles as a versatile platform for the development of active chloride carriers. In the present contribution, we investigate the influence of various electron-withdrawing substituents in positions 3 and 6 of the carbazole core on the chloride transport activity of these anionophores.

Carbazole-Based Colorimetric Anion Sensors.

Owing to their strong carbazole chromophore and fluorophore, as well as to their powerful and convergent hydrogen bond donors, 1,8-diaminocarbazoles are amongst the most attractive and synthetically versatile building blocks for the construction of anion receptors, sensors, and transporters. Aiming to develop carbazole-based colorimetric anion sensors, herein we describe the synthesis of 1,8-diaminocarbazoles substituted with strongly electron-withdrawing substituents, i.e.

Digestive system fistula: a problem still relevant today.

Digestive system fistula originates most frequently as a complication after surgical procedures, less often occurs in the course of inflammatory diseases, but it can also result from neoplasm and injuries. THE AIM OF THE STUDY was to analyze the causes and retrospectively assess the perioperative procedures as well as the results of digestive system fistula treatment. MATERIAL AND METHODS.